Department of Urology, Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, China.
Aging Male. 2020 Dec;23(5):847-853. doi: 10.1080/13685538.2019.1604653. Epub 2019 Apr 23.
This study aimed to evaluate the changes of patients' quality of life (QoL) after cystoprostatectomy as a treatment for locally advanced prostate cancer (LAPC) with the bladder invasion and to determine risk factors for postoperative poor QoL.
Between Jan 2012 and December 2015, 27 patients who received cystoprostatectomy for LAPC with the bladder invasion were retrospectively included. QoL was assessed with the functional assessment of cancer therapy-prostate (FACT-P) questionnaire scores. Determinants for postoperative poor QoL were investigated using univariate and multivariate regression analysis.
Three-year overall survival, biochemical progression-free survival, and clinical progress-free survival were 88.89%, 62.96% and 77.78%, respectively. Preoperative symptoms of hematuria, urinary frequency, and dysuria were well alleviated after cystoprostatectomy. Moreover, FACT-P questionnaire scores at 6 months and 1 year after cystoprostatectomy were significantly higher than preoperative scores. Univariate and multivariable analysis ( < .05) showed that postoperative complication was the independent risk factor for the loss of postoperative QoL.
Patients' QoL can be improved after cystoprostatectomy as the treatment for LAPC with the bladder invasion, which is associated with ameliorative urinary symptoms after the surgery. Besides, surgical complication is identified to be a risk factor for postoperative poor QoL.
本研究旨在评估膀胱癌侵犯局部晚期前列腺癌（LAPC）患者行膀胱全切术后生活质量（QoL）的变化，并确定术后 QoL 较差的危险因素。
回顾性纳入 2012 年 1 月至 2015 年 12 月间因膀胱癌侵犯接受膀胱全切术治疗的 27 例 LAPC 患者。采用癌症治疗功能评估-前列腺量表（FACT-P）问卷评分评估 QoL。采用单因素和多因素回归分析探讨术后 QoL 较差的决定因素。
患者 3 年总生存率、生化无进展生存率和临床无进展生存率分别为 88.89%、62.96%和 77.78%。膀胱全切术后，患者术前血尿、尿频和尿痛等症状均得到明显缓解。此外，膀胱全切术后 6 个月和 1 年的 FACT-P 问卷评分均明显高于术前评分。单因素和多因素分析（<0.05）表明术后并发症是术后 QoL 丧失的独立危险因素。
膀胱癌侵犯局部晚期前列腺癌患者行膀胱全切术治疗后 QoL 可得到改善，这与术后尿路症状改善有关。此外，手术并发症被确定为术后 QoL 较差的危险因素。
