顺铂诱导耳毒性的药物基因组学：研究的成功、不足和未来方向。
Pharmacogenomics of Cisplatin-Induced Ototoxicity: Successes, Shortcomings, and Future Avenues of Research.
机构信息
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
出版信息
Clin Pharmacol Ther. 2019 Aug;106(2):350-359. doi: 10.1002/cpt.1483. Epub 2019 Jun 12.
Cisplatin is a highly effective chemotherapeutic. Unfortunately, its use is limited by cisplatin-induced ototoxicity (CIO). Substantial research has been performed to uncover the genetic variants associated with CIO; however, there has been a lack of consistency in the results that have been reported. This paper aims to provide an overview of the current state of CIO genomics research, delving into the shortcomings of past research, and providing recommendations for future avenues of study.
顺铂是一种非常有效的化疗药物。不幸的是，其使用受到顺铂诱导的耳毒性（CIO）的限制。已经进行了大量研究来揭示与 CIO 相关的遗传变异；然而，报告的结果缺乏一致性。本文旨在提供 CIO 基因组学研究的现状概述，深入探讨过去研究的不足之处，并为未来的研究方向提供建议。
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