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移植项目特定报告改革的时机:AST/ASTS 移植指标工作组。

Time for reform in transplant program-specific reporting: AST/ASTS transplant metrics taskforce.

机构信息

Transplantation Research Center, Renal Division, Brigham& Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Division of Abdominal Transplantation, University of Florida, Gainesville, Florida.

出版信息

Am J Transplant. 2019 Jul;19(7):1888-1895. doi: 10.1111/ajt.15394. Epub 2019 May 23.

Abstract

In accordance with the National Organ Transplant Act and Department of Health and Human Services' Final Rule, the Scientific Registry of Transplant Recipients (SRTR) publicly releases biannual program-specific reports that include analyses of transplant centers' risk-adjusted waitlist mortality, organ acceptance ratios, transplant rates, and graft and patient survival. Since the inception of these center metrics, 1-year posttransplant graft and patient survival have improved, and center variation has decreased, casting uncertainty on their clinical relevance. The SRTR has recently modified center evaluations by ranking centers into 5 tiers rather than 3 tiers in an attempt to discriminate between programs performing within a tight range, further exacerbating this uncertainty. The American Society of Transplantation/American Society of Transplant Surgeons convened an expert taskforce to examine both the utility and unintended consequences of transplant center metrics. Estimates of center variation in outcomes in adjacent tiers are imprecise and fleeting, but can result in consequential changes in clinician and center behavior. The taskforce has concerns that current metrics, based principally on 1-year graft and patient survival, provide minimal if any benefit in informing patient choice and access to transplantation, with the untoward effect of decreased utilization of organs and restriction of research and innovation.

摘要

根据《国家器官移植法》和美国卫生与公众服务部的最终规定,移植受者科学登记处(SRTR)每半年发布一次特定项目的报告,其中包括对移植中心风险调整候补者死亡率、器官接受率、移植率以及移植物和患者存活率的分析。自这些中心指标设立以来,移植后 1 年的移植物和患者存活率有所提高,中心间的差异也有所缩小,这使得这些指标的临床相关性受到质疑。SRTR 最近通过将中心分为 5 个等级,而不是 3 个等级,对中心评估进行了修改,试图区分在严格范围内运作的项目,这进一步加剧了这种不确定性。美国移植协会/美国移植外科学会召集了一个专家工作组,审查移植中心指标的效用和意外后果。对相邻等级中心结果差异的估计不准确且短暂,但可能导致临床医生和中心行为发生重大变化。工作组担心,目前主要基于 1 年移植物和患者存活率的指标,在告知患者选择和接受移植方面几乎没有任何益处,反而会降低器官的利用率,并限制研究和创新。

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