SPLUNC1 Loses Its Antimicrobial Activity in Acidic Cystic Fibrosis Airway Secretions.
作者信息
Ahmad Saira, Gilmore Rodney C, Alexis Neil E, Tarran Robert
机构信息
The University of North Carolina at Chapel HillChapel Hill, North Carolina.
出版信息
Am J Respir Crit Care Med. 2019 Sep 1;200(5):633-636. doi: 10.1164/rccm.201812-2303LE.
Abstract
摘要
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本文引用的文献
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Eur Respir J. 2018 Oct 4;52(4). doi: 10.1183/13993003.00668-2018. Print 2018 Oct.
2
Airway surface liquid pH is not acidic in children with cystic fibrosis.气道表面液体 pH 值在囊性纤维化患儿中并不呈酸性。
Nat Commun. 2017 Nov 10;8(1):1409. doi: 10.1038/s41467-017-00532-5.
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Phenotypes of Rapid Cystic Fibrosis Lung Disease Progression during Adolescence and Young Adulthood.青少年和青年期囊性纤维化肺病快速进展的表型
Am J Respir Crit Care Med. 2017 Aug 15;196(4):471-478. doi: 10.1164/rccm.201612-2574OC.
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Short Palate, Lung, and Nasal Epithelial Clone 1 Has Antimicrobial and Antibiofilm Activities against the Burkholderia cepacia Complex.短腭、肺和鼻上皮克隆1对洋葱伯克霍尔德菌复合体具有抗菌和抗生物膜活性。
Antimicrob Agents Chemother. 2016 Sep 23;60(10):6003-12. doi: 10.1128/AAC.00975-16. Print 2016 Oct.
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pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37.pH调节气道表面液体抗菌剂β-防御素-3和LL-37的活性及协同作用。
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Early respiratory infection is associated with reduced spirometry in children with cystic fibrosis.早期呼吸道感染与囊性纤维化患儿肺功能检测降低有关。
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Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways.囊性纤维化气道中 pH 依赖性黏膜脱水的分子基础。
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