• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
SPLUNC1 Loses Its Antimicrobial Activity in Acidic Cystic Fibrosis Airway Secretions.SPLUNC1在酸性囊性纤维化气道分泌物中丧失其抗菌活性。
Am J Respir Crit Care Med. 2019 Sep 1;200(5):633-636. doi: 10.1164/rccm.201812-2303LE.
2
[Etiopathogenic and therapeutic aspects of chronic respiratory infection in cystic fibrosis].[囊性纤维化慢性呼吸道感染的病因及治疗方面]
Minerva Pediatr. 1986 Jul 31;38(13-14):569-78.
3
SPLUNC1 as a biomarker of pulmonary exacerbations in children with cystic fibrosis.SPLUNC1 作为囊性纤维化患儿肺部恶化的生物标志物。
J Cyst Fibros. 2024 Mar;23(2):288-292. doi: 10.1016/j.jcf.2024.02.009. Epub 2024 Feb 27.
4
Tobacco exposure inhibits SPLUNC1-dependent antimicrobial activity.烟草暴露抑制 SPLUNC1 依赖的抗菌活性。
Respir Res. 2019 May 21;20(1):94. doi: 10.1186/s12931-019-1066-2.
5
Short Palate, Lung, and Nasal Epithelial Clone 1 Has Antimicrobial and Antibiofilm Activities against the Burkholderia cepacia Complex.短腭、肺和鼻上皮克隆1对洋葱伯克霍尔德菌复合体具有抗菌和抗生物膜活性。
Antimicrob Agents Chemother. 2016 Sep 23;60(10):6003-12. doi: 10.1128/AAC.00975-16. Print 2016 Oct.
6
[Mucoviscidosis. Antibiotic management].[黏液黏稠症。抗生素治疗]
Presse Med. 1997;26(15):727-32.
7
microRNAs: a new class of endogenous antimicrobials for the treatment of infections in cystic fibrosis and beyond.微小RNA：一类用于治疗囊性纤维化及其他疾病感染的新型内源性抗菌物质。
Future Microbiol. 2024 Aug 12;19(12):1041-1043. doi: 10.1080/17460913.2024.2357971. Epub 2024 Aug 6.
8
[Bacterial infections and resistance to antibiotics in cystic fibrosis].[囊性纤维化中的细菌感染与抗生素耐药性]
Pediatr Med Chir. 1999 Sep-Oct;21(5 Suppl):213-8.
9
Cystic fibrosis: Part 1.囊性纤维化：第1部分。
Curr Probl Pediatr. 1985 Jun;15(6):1-49. doi: 10.1016/0045-9380(85)90061-1.
10
The Multifunctional Roles of Short Palate, Lung, and Nasal Epithelium Clone 1 in Regulating Airway Surface Liquid and Participating in Airway Host Defense.短腭肺鼻上皮细胞克隆 1 在调节气道表面液体和参与气道宿主防御中的多功能作用。
J Interferon Cytokine Res. 2021 Apr;41(4):139-148. doi: 10.1089/jir.2020.0141.

引用本文的文献

1
Lung antimicrobial proteins and peptides: from host defense to therapeutic strategies.肺部抗菌蛋白和肽：从宿主防御到治疗策略。
Physiol Rev. 2024 Oct 1;104(4):1643-1677. doi: 10.1152/physrev.00039.2023. Epub 2024 Jul 25.
2
CFTR Protein: Not Just a Chloride Channel?CFTR 蛋白：不仅仅是氯离子通道？
Cells. 2021 Oct 22;10(11):2844. doi: 10.3390/cells10112844.
3
A SPLUNC1 Peptidomimetic Inhibits Orai1 and Reduces Inflammation in a Murine Allergic Asthma Model.一种 SPLUNC1 肽模拟物抑制 Orai1 并减少小鼠过敏性哮喘模型中的炎症。
Am J Respir Cell Mol Biol. 2022 Mar;66(3):271-282. doi: 10.1165/rcmb.2020-0452OC.
4
The SPLUNC1-βENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia.SPLUNC1-βENaC 复合物可防止洋葱伯克霍尔德菌在正常气道上皮细胞中的侵袭。
Respir Res. 2020 Jul 17;21(1):190. doi: 10.1186/s12931-020-01454-5.
5
Engineered Cationic Antimicrobial Peptides (eCAPs) to Combat Multidrug-Resistant Bacteria.用于对抗多重耐药细菌的工程化阳离子抗菌肽（eCAPs）
Pharmaceutics. 2020 May 30;12(6):501. doi: 10.3390/pharmaceutics12060501.
6
Mechanisms of Epithelial Immunity Evasion by Respiratory Bacterial Pathogens.呼吸道细菌病原体逃避上皮免疫的机制。
Front Immunol. 2020 Feb 11;11:91. doi: 10.3389/fimmu.2020.00091. eCollection 2020.

本文引用的文献

1
SPLUNC1 degradation by the cystic fibrosis mucosal environment drives airway surface liquid dehydration.囊性纤维化黏膜环境导致 SPALUNC1 降解，从而引发气道表面液体脱水。
Eur Respir J. 2018 Oct 4;52(4). doi: 10.1183/13993003.00668-2018. Print 2018 Oct.
2
Airway surface liquid pH is not acidic in children with cystic fibrosis.气道表面液体 pH 值在囊性纤维化患儿中并不呈酸性。
Nat Commun. 2017 Nov 10;8(1):1409. doi: 10.1038/s41467-017-00532-5.
3
Phenotypes of Rapid Cystic Fibrosis Lung Disease Progression during Adolescence and Young Adulthood.青少年和青年期囊性纤维化肺病快速进展的表型
Am J Respir Crit Care Med. 2017 Aug 15;196(4):471-478. doi: 10.1164/rccm.201612-2574OC.
4
Short Palate, Lung, and Nasal Epithelial Clone 1 Has Antimicrobial and Antibiofilm Activities against the Burkholderia cepacia Complex.短腭、肺和鼻上皮克隆1对洋葱伯克霍尔德菌复合体具有抗菌和抗生物膜活性。
Antimicrob Agents Chemother. 2016 Sep 23;60(10):6003-12. doi: 10.1128/AAC.00975-16. Print 2016 Oct.
5
pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37.pH调节气道表面液体抗菌剂β-防御素-3和LL-37的活性及协同作用。
Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18703-8. doi: 10.1073/pnas.1422091112. Epub 2014 Dec 15.
6
Early respiratory infection is associated with reduced spirometry in children with cystic fibrosis.早期呼吸道感染与囊性纤维化患儿肺功能检测降低有关。
Am J Respir Crit Care Med. 2014 Nov 15;190(10):1111-6. doi: 10.1164/rccm.201407-1277OC.
7
Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways.囊性纤维化气道中 pH 依赖性黏膜脱水的分子基础。
Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):15973-8. doi: 10.1073/pnas.1311999110. Epub 2013 Sep 16.
8
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung.气道表面 pH 值降低会损害猪囊性纤维化肺中的细菌杀伤能力。
Nature. 2012 Jul 4;487(7405):109-13. doi: 10.1038/nature11130.
9
Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium.培养的囊性纤维化支气管上皮细胞对表面液体pH值的异常调节。
Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):16083-8. doi: 10.1073/pnas.2634339100. Epub 2003 Dec 10.

SPLUNC1 Loses Its Antimicrobial Activity in Acidic Cystic Fibrosis Airway Secretions.

作者信息

Ahmad Saira, Gilmore Rodney C, Alexis Neil E, Tarran Robert

机构信息

The University of North Carolina at Chapel HillChapel Hill, North Carolina.

出版信息

Am J Respir Crit Care Med. 2019 Sep 1;200(5):633-636. doi: 10.1164/rccm.201812-2303LE.

DOI:10.1164/rccm.201812-2303LE
PMID:31013116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6727152/
Abstract
摘要