Internal Medicine, University of Campania "L. Vanvitelli", Naples, Italy.
Department of Translational Medical Sciences, "Federico II" University, Naples, Italy.
Clin Transplant. 2019 Jun;33(6):e13574. doi: 10.1111/ctr.13574. Epub 2019 May 7.
Hepatitis B core-related antigen (HBcrAg) has been proposed as a new marker of hepatitis B virus (HBV) replication. We analyzed HBcrAg dynamics in 15 heart transplant recipients with active or prior HBV infection and correlated it with quantitative (QT)-HBsAg and HBV-DNA pre- and post-transplant. Serum HBcrAg was detected in HBsAg/HBV-DNA-positive subjects but not in recipients with past HBV infection. HBcrAg levels correlated with QT-HBsAg in pre- and post-transplant samples. In prior HBV infection, HBcrAg levels were unrelated to HBV-DNA positivity. In heart transplant recipients with prior HBV infection, HBcrAg does not correlate with viral replication and cannot be applied to detect HBV reactivation during follow-up.
乙型肝炎核心相关抗原（HBcrAg）已被提议作为乙型肝炎病毒（HBV）复制的新标志物。我们分析了 15 例有活动性或既往 HBV 感染的心脏移植受者的 HBcrAg 动态，并将其与移植前后定量（QT）-HBsAg 和 HBV-DNA 相关联。HBsAg/ HBV-DNA 阳性的患者可检测到 HBcrAg，而既往 HBV 感染的患者则不能。HBcrAg 水平与移植前后的 QT-HBsAg 相关。在既往 HBV 感染中，HBcrAg 水平与 HBV-DNA 阳性无关。在既往 HBV 感染的心脏移植受者中，HBcrAg 与病毒复制无关，不能用于检测随访期间的 HBV 再激活。
