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乙型肝炎病毒感染的再激活——多方面问题的一个重要方面。

Reactivation of hepatitis B virus infection - an important aspect of multifaceted problem.

作者信息

Morozov Sergey, Batskikh Sergey

机构信息

Department of Gastroenterology, Hepatology and Nutrition, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow 115446, Russia.

Department of Hepatology, Moscow Clinical Scientific Center N.A. A.S. Loginov, Moscow 111123, Russia.

出版信息

World J Gastroenterol. 2024 Jul 14;30(26):3193-3197. doi: 10.3748/wjg.v30.i26.3193.

DOI:10.3748/wjg.v30.i26.3193
PMID:39086636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11287409/
Abstract

In this editorial we comment on the article published in the recent issue of the W. We focus specifically on the problem of occult hepatitis B virus (HBV) infection, that is a result of previous hepatitis B (PHB) and a source for reactivation of HBV. The prevalence of PHB is underestimated due to the lack of population testing programs. However, this condition not only complicate anticancer treatment, but may be responsible for the development of other diseases, like cancer or autoimmune disorders. Here we unveil possible mechanisms responsible for realization of these processes and suggest practical approaches for diagnosis and treatment.

摘要

在这篇社论中,我们对近期《W》期刊上发表的文章进行评论。我们特别关注隐匿性乙型肝炎病毒(HBV)感染问题,它是既往乙型肝炎(PHB)的结果,也是HBV再激活的一个来源。由于缺乏人群检测项目,PHB的患病率被低估了。然而,这种情况不仅使抗癌治疗复杂化,还可能导致其他疾病的发生,如癌症或自身免疫性疾病。在此,我们揭示了导致这些过程发生的可能机制,并提出了诊断和治疗的实用方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f26/11287409/f6fb9b8b9355/WJG-30-3193-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f26/11287409/f6fb9b8b9355/WJG-30-3193-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f26/11287409/f6fb9b8b9355/WJG-30-3193-g001.jpg

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World J Gastroenterol. 2024 Mar 7;30(9):1253-1256. doi: 10.3748/wjg.v30.i9.1253.
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Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies in the targeted therapy era.靶向治疗时代血液系统恶性肿瘤患者乙型肝炎病毒再激活的预防与管理。
World J Gastroenterol. 2023 Sep 7;29(33):4942-4961. doi: 10.3748/wjg.v29.i33.4942.
3
Previous hepatitis B viral infection-an underestimated cause of pancreatic cancer.
既往乙型肝炎病毒感染——被低估的胰腺癌致病因素。
World J Gastroenterol. 2022 Sep 7;28(33):4812-4822. doi: 10.3748/wjg.v28.i33.4812.
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May Previous Hepatitis B Virus Infection Be Involved in Etiology and Pathogenesis of Autoimmune Liver Diseases?既往乙型肝炎病毒感染是否与自身免疫性肝病的病因和发病机制有关?
Adv Ther. 2022 Jan;39(1):430-440. doi: 10.1007/s12325-021-01983-5. Epub 2021 Nov 11.
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Viruses and Autoimmunity: A Review on the Potential Interaction and Molecular Mechanisms.病毒与自身免疫:潜在相互作用和分子机制的综述。
Viruses. 2019 Aug 19;11(8):762. doi: 10.3390/v11080762.
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