Hogeman P H, Veerman A J, Huismans D R, van Zantwijk C H, Bezemer P D
Acta Haematol. 1986;76(2-3):119-23. doi: 10.1159/000206034.
Capping of leukemic cells with a monoclonal antibody against HLA A,B,C determinants was studied in 53 cases of childhood acute lymphoblastic leukemia (ALL). Determination of the percentages of capped cells after different times of incubation with anti-HLA A,B,C show that T ALL and common ALL do have quite different kinetics of HLA capping. In T ALL all cases reach levels of percentage of capped cells above 30%, in common ALL only 11 of 31 cases cap well. Dilution of the antiserum in 6 common ALL cases results in an increase of capped cells, but the original kinetics of the common ALL capping remain. ALL cases with capping curves above 30% have a worse prognosis (shorter continuous complete remission) than cases with capping curves below 30% in the total group as well as in the non-high-risk group.
在53例儿童急性淋巴细胞白血病（ALL）中研究了用抗HLA A、B、C决定簇的单克隆抗体对白血病细胞进行封帽。用抗HLA A、B、C孵育不同时间后测定封帽细胞的百分比，结果显示T-ALL和普通ALL在HLA封帽动力学方面有相当大的差异。在T-ALL中，所有病例封帽细胞百分比均达到30%以上，在普通ALL中，31例中只有11例封帽良好。在6例普通ALL病例中稀释抗血清会导致封帽细胞增加，但普通ALL封帽的原始动力学保持不变。封帽曲线高于30%的ALL病例在整个组以及非高危组中的预后比封帽曲线低于30%的病例更差（持续完全缓解期更短）。
