Isenberg D, Shoenfeld Y
Acta Haematol. 1986;76(2-3):95-100. doi: 10.1159/000206029.
The establishment of mouse and human monoclonal anti-DNA antibodies is described. Common idiotypes were identified on these antibodies employing monoclonal (mouse) and polyclonal anti-idiotypic antibodies. The significance of the presence and titer of the common idiotypes as clinical activity marker was examined in patients with systemic lupus erythematosus. Based on Jerne's network theory [Ann. Immunol. 125c: 373-389, 1974], naturally occurring anti-idiotypic antibodies to anti-DNA antibodies were reported. The utilization of this information to understand autoimmunity is discussed.
本文描述了小鼠和人单克隆抗DNA抗体的建立。利用单克隆（小鼠）和多克隆抗独特型抗体鉴定了这些抗体上的共同独特型。在系统性红斑狼疮患者中，研究了共同独特型的存在和滴度作为临床活动标志物的意义。基于耶尔恩的网络理论[《免疫学年报》125c：373 - 389，1974年]，报道了天然存在的抗DNA抗体的抗独特型抗体。本文还讨论了利用这些信息来理解自身免疫。
