Bauman G P, Hurtubise P
University of Cincinnati Medical College, Ohio.
Clin Lab Med. 1988 Jun;8(2):399-407.
Idiotypes represent structural sites located on the Fab fragment of antibodies. Even though these sites are combining sites for antigenic determinant, their uniqueness makes them antigenic, generating anti-Ids that have functionally performed as suppressive agents for the further production of the antibody. Jerne's network theory of idiotypes has provided a basis upon which investigators have searched for means to reduce, or explain the reduction of, Ab production. A principal area of this reduction of Ab expression concerns the autoAbs in autoimmune diseases. Experimental and clinical evidence suggests a role for anti-Ids in suppressing autoAb production and an inverse relationship between serum levels of anti-Ids and autoimmune disease activity.
独特型代表位于抗体Fab片段上的结构位点。尽管这些位点是抗原决定簇的结合位点，但它们的独特性使其具有抗原性，可产生抗独特型抗体，这些抗独特型抗体在功能上可作为抑制抗体进一步产生的因子。杰内的独特型网络理论为研究人员寻找减少或解释抗体产生减少的方法提供了基础。抗体表达减少的一个主要领域涉及自身免疫性疾病中的自身抗体。实验和临床证据表明抗独特型抗体在抑制自身抗体产生中起作用，且抗独特型抗体血清水平与自身免疫性疾病活动之间呈负相关。
