Achol Emmanuel, Ochaya Stephen, Malinga Geoffrey M, Edema Hillary, Echodu Richard
Department of Biology, Faculty of Science, Gulu University, P.O. Box 166, Gulu, Uganda.
Gulu University Bioscience Research Laboratories, P.O. Box 166, Gulu, Uganda.
BMC Res Notes. 2019 Apr 23;12(1):235. doi: 10.1186/s13104-019-4269-1.
To determine the prevalence of Plasmodium falciparum multi-drug resistant gene-1 (Pfmdr-1) N86Y and D1246Y genotypes among febrile malaria outpatients attending Lira Regional Referral Hospital, Uganda.
Overall, 92.3% (n = 48/52) and 90% (n = 45/50) of the parasites detected carried the wild type alleles 1246D and N86, respectively. Only 7.7% (n = 4/52) and 10% (n = 5/50) of these P. falciparum isolates carried the Pfmdr-1 mutant alleles 1246Y and 86Y, respectively. Our results show high prevalence of wild type alleles N86 and D1246 in P. falciparum isolates from Lira Regional Referral Hospital, which could translate to a decreased sensitivity to artemether-lumefantrine. Continued monitoring of prevalence of single nucleotide polymorphisms is warranted to timely inform malaria treatment policies and guidelines.
确定乌干达利拉地区转诊医院发热性疟疾门诊患者中恶性疟原虫多药耐药基因1（Pfmdr-1）N86Y和D1246Y基因型的流行情况。
总体而言，检测到的疟原虫中分别有92.3%（n = 48/52）和90%（n = 45/50）携带野生型等位基因1246D和N86。这些恶性疟原虫分离株中分别只有7.7%（n = 4/52）和10%（n = 5/50）携带Pfmdr-1突变等位基因1246Y和86Y。我们的结果显示，利拉地区转诊医院的恶性疟原虫分离株中野生型等位基因N86和D1246的流行率很高，这可能导致对蒿甲醚-本芴醇的敏感性降低。有必要持续监测单核苷酸多态性的流行情况，以便及时为疟疾治疗政策和指南提供依据。
