Sharma Mousmee, Prasher Parteek
Department of Chemistry , Uttaranchal University , Dehradun 248007 , India.
UGC Sponsored Centre for Advanced Studies , Department of Chemistry , Guru Nanak Dev University , Amritsar 143005 , India.
RSC Med Chem. 2019 Dec 23;11(2):184-211. doi: 10.1039/c9md00479c. eCollection 2020 Feb 1.
The development of multidrug resistance in the malarial parasite has sabotaged majority of the eradication efforts by restraining the inhibition profile of first line as well as second line antimalarial drugs, thus necessitating the development of novel pharmaceutics constructed on appropriate scaffolds with superior potency against the drug-resistant and drug-susceptible parasite. Over the past decades, the infectious malarial parasite has developed resistance against most of the contemporary therapeutics, thus necessitating the rational development of novel approaches principally focused on MDR malaria. This review presents an epigrammatic collation of the epidemiology and the contemporary antimalarial therapeutics based on the '' motif.
疟原虫多药耐药性的发展破坏了大多数根除疟疾的努力，因为它限制了一线和二线抗疟药物的抑制作用，因此需要开发基于合适支架的新型药物，这些药物对耐药和敏感疟原虫具有更高的效力。在过去几十年中，感染性疟原虫已对大多数当代疗法产生耐药性，因此有必要合理开发主要针对耐多药疟疾的新方法。本综述基于“主题”对疟疾流行病学和当代抗疟疗法进行了简要整理。
