肥大细胞数量的增加与 2 型糖尿病大鼠胰岛β细胞质量和再生的减少有关。
Increased mast cell number is associated with a decrease in beta-cell mass and regeneration in type 2 diabetic rats.
机构信息
Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt.
Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt; Department of Basic Medical Sciences, Unit of Anatomy, Unaizah College of Medicine, Qassim University, Al Qassim, Saudi Arabia.
出版信息
Acta Histochem. 2019 May;121(4):508-515. doi: 10.1016/j.acthis.2019.04.009. Epub 2019 Apr 20.
The role of mast cells (MCs) in type 2 diabetes (T2D) is not thoroughly studied as much as in T1D. Therefore in the current study we investigated correlation between these cells and various parameters of islets of Langerhans (IOL) in rats which were equally divided (n = 40) into; control and diabetic groups. We detected a significantly increased (p < 0.05) MC count (MCC) in the diabetic IOL compared to the control, together with a noticeable intra-islet seeding of these cells which displayed a tryptase positive immunostaining. A significant positive correlation (p < 0.05) between MCC and the % of glucagon cells per islet was detected in DM, unlike mass of the islets, mass of β-cells, and % of β-cells per islet which were negatively correlated with MCC. Similarly, there was a negative correlation between MCC with β-cell proliferation and neogenesis frequency in DM. This highlights the potential association between the increased MC number and the diminished islet`s mass as well as regeneration which may fasten the progression of T2D.
肥大细胞（MCs）在 2 型糖尿病（T2D）中的作用尚未像在 1 型糖尿病（T1D）中那样得到充分研究。因此，在目前的研究中，我们调查了这些细胞与大鼠胰岛（IOL）各种参数之间的相关性，这些大鼠被平均分为（n=40）对照组和糖尿病组。我们发现，与对照组相比，糖尿病 IOL 中的 MC 计数（MCC）显著增加（p<0.05），并且这些细胞在胰岛内有明显的定植，呈现出胰蛋白酶阳性免疫染色。在 DM 中，我们检测到 MCC 与每个胰岛的胰高血糖素细胞的%之间存在显著的正相关（p<0.05），而胰岛的质量、β-细胞的质量和每个胰岛的β-细胞的%与 MCC 呈负相关。同样，在 DM 中，MCC 与β-细胞增殖和新生频率之间也存在负相关。这突出表明，MC 数量的增加与胰岛质量的减少以及再生之间存在潜在的关联，这可能会加速 T2D 的进展。
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