α-硫辛酸在自身免疫性疾病中的免疫调节作用。
The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases.
作者信息
Liu Wei, Shi Lian-Jie, Li Sheng-Guang
机构信息
Department of Respiratory and Critical Care Medicine, The 900th Hospital of the Joint Logistic Support Force, PLA, Fujian Medical University, Fuzhou 350025, China.
Department of Rheumatology and immunology, Peking University International Hospital, Beijing 102206, China.
出版信息
Biomed Res Int. 2019 Mar 20;2019:8086257. doi: 10.1155/2019/8086257. eCollection 2019.
Αlpha-lipoic acid is a naturally occurring antioxidant in human body and has been widely used as an antioxidant clinically. Accumulating evidences suggested that -lipoic acid might have immunomodulatory effects on both adaptive and innate immune systems. This review focuses on the evidences and potential targets involved in the immunomodulatory effects of -lipoic acid. It highlights the fact that -lipoic acid may have beneficial effects in autoimmune diseases once the immunomodulatory effects can be confirmed by further investigation.
α-硫辛酸是人体中天然存在的抗氧化剂，在临床上已被广泛用作抗氧化剂。越来越多的证据表明，α-硫辛酸可能对适应性免疫系统和先天性免疫系统都具有免疫调节作用。本综述聚焦于α-硫辛酸免疫调节作用所涉及的证据及潜在靶点。它强调了这样一个事实，即一旦通过进一步研究证实α-硫辛酸的免疫调节作用，其可能在自身免疫性疾病中产生有益效果。
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