dl-α-硫辛酸对老年大鼠脂质过氧化状态和抗氧化剂的影响。
Effect of dl-alpha-lipoic acid on the status of lipid peroxidation and antioxidants in aged rats.
作者信息
Arivazhagan P, Juliet P, Panneerselvam C
机构信息
Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113, India.
出版信息
Pharmacol Res. 2000 Mar;41(3):299-303. doi: 10.1006/phrs.1999.0594.
The effect of dl-alpha-lipoic acid on lipid peroxidation and antioxidants status has been studied in the blood of young and aged rats. dl-alpha-lipoic acid, an antioxidant, was administered intraperitoneally for 7 and 14 days. Enzymatic and non-enzymatic antioxidant levels decreased with age but this decrease was attenuated by dl-alpha-lipoic acid. Lipid peroxide levels increased with age, and were decreased by lipoic acid administration. These results suggest that biochemical lesions which are considered to be part of the normal ageing process are neutralized by dl-alpha-lipoic acid.
已在幼年和老年大鼠的血液中研究了dl-α-硫辛酸对脂质过氧化和抗氧化剂状态的影响。抗氧化剂dl-α-硫辛酸经腹腔注射给药7天和14天。酶促和非酶促抗氧化剂水平随年龄增长而降低，但这种降低被dl-α-硫辛酸减弱。脂质过氧化物水平随年龄增长而升高，而硫辛酸给药可使其降低。这些结果表明，被认为是正常衰老过程一部分的生化损伤被dl-α-硫辛酸中和。
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