Lobov G I, Dvoretskii D P
Pavlov Institute of Physiology, Russian Academy of Sciences, 199034, St. Petersburg, Russia.
Dokl Biol Sci. 2019 May;484(1):10-12. doi: 10.1134/S001249661901006X. Epub 2019 Apr 23.
Endothelium-dependent relaxation mechanisms have been studied in phenylephrine-precontracted capsules of bovine mesenteric lymph nodes studied in vitro. Tetraethylammonium chloride and TRAM-34 in a solution with L-NAME and Indomethacin, which suppress the production NO and prostacyclin of endothelium, increased the tone of the lymph nodes. We believe that in bovine mesenteric lymph nodes, the dilation mechanism is mediated by hyperpolarization of the endothelium, which is associated with activation of large- and intermedium conductance Ca-activated potassium channels.
在体外研究了苯肾上腺素预收缩的牛肠系膜淋巴结包膜中的内皮依赖性舒张机制。在含有L-精氨酸甲酯（L-NAME）和吲哚美辛的溶液中，四乙铵氯化物和TRAM-34抑制内皮细胞一氧化氮（NO）和前列环素的产生，增加了淋巴结的张力。我们认为，在牛肠系膜淋巴结中，舒张机制是由内皮细胞超极化介导的，这与大电导和中间电导钙激活钾通道的激活有关。
