分枝杆菌素对黑曲霉摄取可释放细胞物质的选择性作用。
Selective action of mycobacillin on the uptake of releasable cell materials by Aspergillus niger.
作者信息
Das S K, Basu S, Majumdar S, Bose S K
出版信息
Biochem J. 1986 Oct 15;239(2):317-23. doi: 10.1042/bj2390317.
The uptake of normally releasable (i.e. releasable in the absence of the antibiotic) cell constituents (namely lysine, proline, ATP, Pi, Na+, K+ and Ca2+) by sensitive cells of Aspergillus niger that occurs in the absence of mycobacillin is gradually enhanced with increase in concentration of the antibiotic until the uptake attains the maximum. With still higher concentrations the uptake decreases until it becomes the same as in the control without mycobacillin. Uptake follows saturation kinetics both in the absence and in the presence of the antibiotic. Mycobacillin significantly increases Vmax. for uptake with any effect on Km, Mycobacillin has no action on the uptake of non-releasable materials.
在不存在分枝杆菌素的情况下，黑曲霉敏感细胞对正常可释放（即在无抗生素时可释放）的细胞成分（即赖氨酸、脯氨酸、ATP、无机磷、Na⁺、K⁺和Ca²⁺）的摄取，会随着抗生素浓度的增加而逐渐增强，直至摄取达到最大值。当浓度更高时，摄取量下降，直至与无分枝杆菌素的对照相同。无论有无抗生素，摄取均遵循饱和动力学。分枝杆菌素显著增加摄取的Vmax，而对Km无影响。分枝杆菌素对不可释放物质的摄取无作用。
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