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柔性核酸（FNA）作为信息分子：fNTP在DNA模板上的酶促聚合以及RNA在FNA模板上的非酶促寡聚化。

Flexible Nucleic Acids (FNAs) as Informational Molecules: Enzymatic Polymerization of fNTPs on DNA Templates and Nonenzymatic Oligomerization of RNA on FNA Templates.

作者信息

Chemama Maryline, Switzer Christopher

机构信息

Department of Chemistry, University of California, Riverside, Riverside, CA, USA.

出版信息

Methods Mol Biol. 2019;1973:213-236. doi: 10.1007/978-1-4939-9216-4_14.

DOI:10.1007/978-1-4939-9216-4_14

PMID:31016705

Abstract

The methodology enabling enzymatic and nonenzymatic information transfer with FNAs is described. This methodology includes the chemical synthesis of fNTPs and fN phosphoramidites, in addition to protocols for the enzymatic and nonenzymatic transfer of information.

摘要

描述了实现通过FNA进行酶促和非酶促信息传递的方法。该方法除了包括信息酶促和非酶促传递的方案外，还包括fNTP和fN亚磷酰胺的化学合成。