微粒体细胞色素P-450催化花生四烯酸氧化过程中形成的羟基二十碳四烯酸（HETEs）的绝对构型。
Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450.
作者信息
Capdevila J, Yadagiri P, Manna S, Falck J R
出版信息
Biochem Biophys Res Commun. 1986 Dec 30;141(3):1007-11. doi: 10.1016/s0006-291x(86)80144-9.
PMID:3101677
Abstract
Rat liver microsomal cytochrome P-450 catalyzes the NADPH dependent metabolism of arachidonic acid to six regioisomeric cis,trans-dienols. The 12(R)-hydroxyeicosatetraenoic acid is generated with a high degree of enantioselectivity while the remaining regioisomers are produced as nearly racemic mixtures.
摘要
大鼠肝脏微粒体细胞色素P-450催化花生四烯酸的NADPH依赖性代谢生成六种区域异构体顺式、反式二烯醇。12(R)-羟基二十碳四烯酸以高度对映选择性生成，而其余区域异构体则以近乎外消旋混合物的形式产生。
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