Audouin J, Le Tourneau A, Marche C, Diebold J
Ann Pathol. 1986;6(4-5):271-4.
The authors describe the immunopathological findings in the different histopathological types. In type IA, the most important findings are disruption of the network of the intrafollicular dendritic cells, progressive atrophy of the mantle zone as shown with anti-delta antibody, the progressive diminution of the number of CD4 cells first in the germinative centres then in the extrafollicular areas, the progressive increase of CD8 cells first in the germinative centres, the presence of a severe B cells hyperplasia which is polytypic. In type II, the most important findings are the global decrease of T cells predominantly of CD4 cells. These alterations of the repartition of B and T cells is highly suggestive in type IA for LAV infection. These findings have some interest for the understanding of the physiopathology of the disease.
作者描述了不同组织病理学类型中的免疫病理学发现。在IA型中，最重要的发现是滤泡内树突状细胞网络的破坏，用抗δ抗体显示的套区进行性萎缩，生发中心的CD4细胞数量首先逐渐减少，然后在滤泡外区域也减少，生发中心的CD8细胞数量首先逐渐增加，存在严重的多型性B细胞增生。在II型中，最重要的发现是T细胞整体减少，主要是CD4细胞减少。B细胞和T细胞分布的这些改变在IA型中高度提示为淋巴细胞相关病毒（LAV）感染。这些发现对于理解该疾病的生理病理学具有一定意义。
