Diebold J, Audouin J, Marche C, Le Tourneau A
Ann Pathol. 1986;6(4-5):266-70.
The histopathological modifications of the lymph nodes are studied in patients at risk for AIDS, LAV positive, with the lymphadenopathy syndrome (LAS) or the ARC. Three different types are described: type IA, with predominantly a severe follicular hyperplasia, type IB with angiofollicular hyperplasia or Castleman disease like lesions, type II with angioimmunoblastic like lesions. In type IA, the modifications of the follicles are the most important histological modification (atrophy of the mantle zone, germinative centres lymphoid infiltrate). These lesions are non specific. But associated to modifications of the deep cortical area and the sinuses they are highly suggestive of the diagnosis of LAV infection. A correlation is shown between evolution and histopathological lesions. The lymph node biopsy in patients at risk for AIDS is useful for the diagnosis and also the prognosis.
对处于艾滋病风险、LAV呈阳性、患有淋巴结病综合征（LAS）或艾滋病相关综合征（ARC）的患者的淋巴结组织病理学改变进行了研究。描述了三种不同类型：IA型，主要为严重的滤泡增生；IB型，伴有血管滤泡增生或类卡斯特曼病病变；II型，伴有血管免疫母细胞样病变。在IA型中，滤泡的改变是最重要的组织学改变（套区萎缩、生发中心淋巴细胞浸润）。这些病变是非特异性的。但与深部皮质区和窦的改变相关时，它们强烈提示LAV感染的诊断。研究显示了病情演变与组织病理学病变之间的相关性。对处于艾滋病风险的患者进行淋巴结活检对诊断和预后都有用。
