Ge Xin-Yu, Lei Li-Wang, Ge Fei, Jiang Xian
a Department of General Surgery , The First Affiliated Hospital of Harbin Medical University , Harbin , PR China.
Scand J Gastroenterol. 2019 Apr;54(4):480-484. doi: 10.1080/00365521.2019.1604798. Epub 2019 Apr 24.
To investigate the risk factors affecting the survival of patients with gastrointestinal stromal tumors (GISTs) in different age groups. Information on 6089 GIST patients was screened from the Surveillance, Epidemiology, and End Results (SEER) database. Risk factor analysis was performed using a chi-square test (univariate analysis). Survival analysis was performed using the Kaplan-Meier method (log-rank test) and the COX proportional hazard model. Value < .05 was considered statistically significant. Analyzed statistically to reveal that in addition to tumor size, mitotic index, and primary location, age, gender, race, and surgical treatment also were independent risk factors for GISTs. Gender, race, and location of disease influenced the survival rate of patients, which was higher in the young group (≤60 years old) than the elderly group (>60 years). Risk factors such as primary location, tumor diameter, and mitotic index varied significantly between the different age groups. Age, gender, race, and surgical treatment are independent risk factors that influence the prognosis in patients with GISTs. Some risk factors affecting prognosis are age dependent.
探讨影响不同年龄组胃肠道间质瘤（GISTs）患者生存的危险因素。从监测、流行病学和最终结果（SEER）数据库中筛选出6089例GIST患者的信息。采用卡方检验（单因素分析）进行危险因素分析。采用Kaplan-Meier法（对数秩检验）和COX比例风险模型进行生存分析。P值<0.05被认为具有统计学意义。经统计学分析发现，除肿瘤大小、有丝分裂指数和原发部位外，年龄、性别、种族和手术治疗也是GISTs的独立危险因素。性别、种族和疾病部位影响患者的生存率，年轻组（≤60岁）高于老年组（>60岁）。不同年龄组之间，原发部位、肿瘤直径和有丝分裂指数等危险因素存在显著差异。年龄、性别、种族和手术治疗是影响GISTs患者预后的独立危险因素。一些影响预后的危险因素与年龄有关。
