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Notch 信号通路影响口腔肿瘤细胞分化和获得肿瘤特异性特征。

Notch Signaling Affects Oral Neoplasm Cell Differentiation and Acquisition of Tumor-Specific Characteristics.

机构信息

Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.

Department of Oral Pathology, School of Dentistry, Aichi Gakuin University, Nagoya 464-8650, Japan.

出版信息

Int J Mol Sci. 2019 Apr 23;20(8):1973. doi: 10.3390/ijms20081973.

DOI:10.3390/ijms20081973
PMID:31018488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6514842/
Abstract

Histopathological findings of oral neoplasm cell differentiation and metaplasia suggest that tumor cells induce their own dedifferentiation and re-differentiation and may lead to the formation of tumor-specific histological features. Notch signaling is involved in the maintenance of tissue stem cell nature and regulation of differentiation and is responsible for the cytological regulation of cell fate, morphogenesis, and/or development. In our previous study, immunohistochemistry was used to examine Notch expression using cases of odontogenic tumors and pleomorphic adenoma as oral neoplasms. According to our results, Notch signaling was specifically associated with tumor cell differentiation and metaplastic cells of developmental tissues. Notch signaling was involved in the differentiation of the ductal epithelial cells of salivary gland tumors and ameloblast-like cells of odontogenic tumors. However, Notch signaling was also involved in squamous metaplasia, irrespective of the type of developmental tissue. In odontogenic tumors, Notch signaling was involved in epithelial-mesenchymal interactions and may be related to tumor development and tumorigenesis. This signaling may also be associated with the malignant transformation of ameloblastomas. Overall, Notch signaling appears to play a major role in the formation of the characteristic cellular composition and histological features of oral neoplasms, and this involvement has been reviewed here.

摘要

口腔肿瘤细胞分化和化生的组织病理学发现表明，肿瘤细胞诱导自身去分化和再分化，并可能导致肿瘤特异性组织学特征的形成。Notch 信号通路参与组织干细胞特性的维持和分化的调节，负责细胞命运、形态发生和/或发育的细胞学调节。在我们之前的研究中，使用牙源性肿瘤和多形性腺瘤作为口腔肿瘤，通过免疫组织化学检查 Notch 表达。根据我们的结果，Notch 信号通路与肿瘤细胞分化和发育组织的化生细胞特异性相关。Notch 信号通路参与唾液腺肿瘤的导管上皮细胞和牙源性肿瘤的成釉细胞样细胞的分化。然而，Notch 信号通路也参与鳞状化生，而与发育组织的类型无关。在牙源性肿瘤中，Notch 信号通路参与上皮-间充质相互作用，可能与肿瘤发生和肿瘤发生有关。这种信号通路也可能与成釉细胞瘤的恶性转化有关。总的来说，Notch 信号通路似乎在口腔肿瘤特征性细胞组成和组织学特征的形成中起主要作用，这里对其参与进行了综述。

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WNT and NOTCH signaling pathways as activators for epidermal growth factor receptor in esophageal squamous cell carcinoma.WNT 和 NOTCH 信号通路作为食管鳞癌表皮生长因子受体的激活剂。
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The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes.
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Med Sci Monit. 2020 Jan 28;26:e921863. doi: 10.12659/MSM.921863.
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