Ibrahim Faten Y, El-Khateeb Ayman Y, Mohamed Azza H
Food Industries Department, Faculty of Agriculture, Mansoura University, Mansoura 35511, Egypt.
Agricultural Chemistry Department, Faculty of Agriculture, Mansoura University, Mansoura 35511, Egypt.
Foods. 2019 Apr 23;8(4):139. doi: 10.3390/foods8040139.
Green synthesis of metal nanoparticles using plant extracts offers a safe and attractive alternate to the chemical methods. The present work aims at preparing metal nanoparticles of rhus ( L.) and safflower ( L.) extracts using Fe, Cu, Zn, and Ag ions. The water extracts were prepared, and the total polyphenols and flavonoids contents were determined. The safflower extract contained the highest number of total polyphenols and total flavonoids (87.20 mg GAE/g and 36.32 mg QE/g), respectively. The synthesized nanoparticles were characterized using UV-Visible (UV-Vis) spectroscopy and Transmission Electron Microscope (TEM). The studied extracts and their nanoparticles were evaluated as an antioxidant, antimicrobial, and anticancer agents. The plant extracts and their nanoparticles showed significant antioxidant activity using (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assays. Safflower silver nanoparticles (AgNPs) were the most powerful antimicrobial agent compared to the other nanoparticles. The Sulforhodamine B (SRB) cytotoxic activity was evaluated against three cancer cell lines. The results revealed that CuNP safflower nanoparticles displayed the highest activity as anticancer agent with values (98.94% with T47D, 97.68% with HEPG2, and 89.33% against Caco-2). The data revealed that rhus and safflower extracts and their nanoparticles possess high potential activity as antimicrobial, antioxidant, and anticancer agents.
利用植物提取物绿色合成金属纳米颗粒为化学方法提供了一种安全且有吸引力的替代方案。本研究旨在用铁、铜、锌和银离子制备盐肤木和红花提取物的金属纳米颗粒。制备了水提取物，并测定了总多酚和黄酮类化合物的含量。红花提取物的总多酚和总黄酮含量最高，分别为87.20毫克没食子酸当量/克和36.32毫克芦丁当量/克。使用紫外可见光谱（UV-Vis）和透射电子显微镜（TEM）对合成的纳米颗粒进行了表征。对所研究的提取物及其纳米颗粒进行了抗氧化、抗菌和抗癌剂的评估。植物提取物及其纳米颗粒在（3-乙基苯并噻唑啉-6-磺酸（ABTS）和2,2-二苯基-1-苦基肼（DPPH）测定中显示出显著的抗氧化活性。与其他纳米颗粒相比，红花银纳米颗粒（AgNPs）是最有效的抗菌剂。对三种癌细胞系评估了磺酰罗丹明B（SRB）细胞毒性活性。结果显示，红花铜纳米颗粒作为抗癌剂活性最高，对T47D细胞的抑制率为98.94%，对HEPG2细胞的抑制率为97.68%，对Caco-2细胞的抑制率为89.33%。数据表明，盐肤木和红花提取物及其纳米颗粒作为抗菌、抗氧化和抗癌剂具有很高的潜在活性。
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