Department of Neurosurgery, Beijing Shijitan Hospital, Capital Medical University, China.
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, China.
Biochem Biophys Res Commun. 2019 Jun 18;514(1):51-57. doi: 10.1016/j.bbrc.2019.04.120. Epub 2019 Apr 21.
Krüppel-like factors (KLFs) are zinc-finger transcriptional factors that regulate target gene expression. Recent studies have shown that KLFs play essential roles in cancer development, whereas the function of KLF7 in glioma remains unclear. In this study, we showed that KLF7 was up-regulated in glioma tissues and its expression was inversely correlated with the patients' survival. Functional experiments demonstrated that KLF7 promoted the proliferation, migration and tumorigenesis of glioma cells. Mechanistically, KLF7 transcriptionally activated argininosuccinate lyase (ASL), which was observed highly expressed in glioma tissues. The biosynthesis of polyamine, a urea cycle metabolite, was enhanced by KLF7 in glioma cells. In addition, ASL contributed to the growth of glioma cells triggered by KLF7. Our findings demonstrate KLF7 as an oncogene and link KLF7 to ASL-mediated polyamine metabolism in glioma.
Krüppel 样因子 (KLFs) 是锌指转录因子，可调节靶基因的表达。最近的研究表明，KLFs 在癌症发展中发挥着重要作用，而 KLF7 在神经胶质瘤中的功能尚不清楚。在本研究中，我们表明 KLF7 在神经胶质瘤组织中上调，其表达与患者的生存呈负相关。功能实验表明 KLF7 促进了神经胶质瘤细胞的增殖、迁移和致瘤性。机制上，KLF7 转录激活精氨酸琥珀酸裂解酶 (ASL)，ASL 在神经胶质瘤组织中高表达。KLF7 在神经胶质瘤细胞中增强了尿素循环代谢产物多胺的生物合成。此外，ASL 有助于 KLF7 触发的神经胶质瘤细胞的生长。我们的研究结果表明 KLF7 是一种癌基因，并将 KLF7 与神经胶质瘤中 ASL 介导的多胺代谢联系起来。
