Department of Histology and Embryology/Key Laboratory of Xinjiang Endemic and Ethnic Diseases of Ministry of Education, Shihezi University School of Medicine, Shihezi 832000, China.
Department of Reproductive Medicine, The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi 832000, China.
Acta Biochim Biophys Sin (Shanghai). 2023 May 24;55(5):713-725. doi: 10.3724/abbs.2023061.
Krüppel-like factor 7 ( ), also named ubiquitous ( ) based on its ubiquitous expression in adult human tissues, is a conserved gene in animals. There are few reports on KLF7 among KLFs; however, an increasing number of reports are demonstrating that KLF7 plays an important role in development and diseases. Genetic studies have shown that the DNA polymorphisms of are associated with obesity, type 2 diabetes mellitus (T2DM), lachrymal/salivary gland lesions, and mental development in some populations of humans, and the DNA methylation of is associated with the development of diffuse gastric cancer. In addition, biological function studies have shown that KLF7 regulates the development of the nervous system, adipose tissue, muscle tissue and corneal epithelium as well as the preservation of pluripotent stem cells. Additionally, disease-related studies have shown that KLF7 is involved in the development or progression of T2DM, hematologic diseases, lung cancer, gastric cancer, squamous cell carcinoma of the head and neck, pancreatic ductal adenocarcinoma, glioma, advanced high-grade serous ovarian cancer and osteosarcoma. This review provides research progress on the genetic association, molecular properties and biological function of KLF7, and it may shed light on the understanding of the molecular function of KLF7 in biology and the molecular mechanisms of some diseases.
Krüppel 样因子 7（Krüppel-like factor 7，KLF7），又称普遍存在的因子（ubiquitous factor），因其在成人组织中的普遍表达而得名，是一种在动物中保守的基因。在 KLF 家族中，关于 KLF7 的报道较少；然而，越来越多的报道表明 KLF7 在发育和疾病中发挥着重要作用。遗传研究表明，的 DNA 多态性与肥胖、2 型糖尿病（type 2 diabetes mellitus，T2DM）、泪腺/唾液腺病变和某些人群的精神发育有关，的 DNA 甲基化与弥漫性胃癌的发生有关。此外，生物学功能研究表明，KLF7 调节神经系统、脂肪组织、肌肉组织和角膜上皮的发育以及多能干细胞的保存。此外，疾病相关研究表明，KLF7 参与 T2DM、血液疾病、肺癌、胃癌、头颈部鳞状细胞癌、胰腺导管腺癌、神经胶质瘤、高级别浆液性卵巢癌和骨肉瘤的发生或进展。本综述提供了关于 KLF7 的遗传关联、分子特性和生物学功能的研究进展，这可能有助于理解 KLF7 在生物学中的分子功能和某些疾病的分子机制。
