Focusing of the regulatory T-cell repertoire after allogeneic stem cell transplantation indicates protection from graft--host disease.
作者信息
Odak Ivan, Raha Solaiman, Schultze-Florey Christian, Tavil Saleh, Ravens Sarina, Ganser Arnold, Förster Reinhold, Prinz Immo, Koenecke Christian
机构信息
Institute of Immunology, Hannover Medical School.
Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
出版信息
Haematologica. 2019 Dec;104(12):e577-e580. doi: 10.3324/haematol.2019.218206. Epub 2019 Apr 24.
Abstract
摘要
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T-cell receptor-α repertoire of CD8+ T cells following allogeneic stem cell transplantation using next-generation sequencing.采用下一代测序技术对异基因干细胞移植后 CD8+T 细胞的 T 细胞受体-α 进行研究。
Haematologica. 2019 Mar;104(3):622-631. doi: 10.3324/haematol.2018.199802. Epub 2018 Sep 27.
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Generation and Characterization of Alloantigen-Specific Regulatory T Cells For Clinical Transplant Tolerance.同种异体抗原特异性调节性 T 细胞的生成与鉴定用于临床移植耐受。
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Quantifiable predictive features define epitope-specific T cell receptor repertoires.可量化的预测特征定义了表位特异性T细胞受体库。
Nature. 2017 Jul 6;547(7661):89-93. doi: 10.1038/nature22383. Epub 2017 Jun 21.
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Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection.人 γδ T 细胞在干细胞移植后迅速重建，并在病毒感染时表现出适应性克隆扩增。
Nat Immunol. 2017 Apr;18(4):393-401. doi: 10.1038/ni.3686. Epub 2017 Feb 20.
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Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity.具有单一TCR特异性的调节性T细胞对致死性自身免疫的抑制作用。
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T cell receptor repertoires after adoptive transfer of expanded allogeneic regulatory T cells.扩增后的同种异体调节性T细胞过继转移后的T细胞受体库
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