Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine, Yufu, Oita 879-5593, Japan.
Department of Gastroenterological and Pediatric Surgery, Oita University, Yufu, Oita 879-5593, Japan.
Endocr J. 2019 Jul 28;66(7):605-613. doi: 10.1507/endocrj.EJ18-0543. Epub 2019 Apr 23.
In this study, we investigated the relationships between body weight (BW), computed tomography (CT)-assessed abdominal adipose tissue, and the glycemic metabolic profile in obese Japanese patients following laparoscopic sleeve gastrectomy (LSG). This study analyzed adipose tissue compartments using CT methods before and 1 year after LSG. Thirty obese patients were studied, and variables measured included visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), density of VAT (VAT-D), and density of SAT (SAT-D). We also examined the parameters in patients according to whether they had type-2 diabetes (T2DM). LSG induced significant losses in BW, SAT, and VAT after LSG. Additionally, SAT-D and VAT-D both increased and fasting plasma glucose (FPG) and HbA1c, but not C-peptide, decreased after surgery. ΔSAT and ΔVAT were positively related, and ΔSAT-D and ΔVAT-D were negatively related to ΔBW and/or FPG. Furthermore, a multivariate regression model showed that total BW loss (TBWL) was closely related to ΔSAT (β = 0.84; p < 0.001) and ΔVAT-D (β = -0.45; p < 0.05) and improvement of FPG was related to ΔVAT (β = 0.61; p < 0.05) after LSG. Finally, ΔFPG was correlated with ΔVAT in 16 T2DM patients (r = 0.58; p < 0.05) but not in non-T2DM patients. TBWL was related to ΔSAT and ΔVAT-D, and improvement of FPG was related to ΔVAT in obese Japanese patients after LSG.
在这项研究中，我们调查了肥胖日本患者腹腔镜袖状胃切除术（LSG）后体重（BW）、计算机断层扫描（CT）评估的腹部脂肪组织与血糖代谢特征之间的关系。本研究使用 CT 方法分析了 LSG 前后的脂肪组织隔室。研究了 30 名肥胖患者，测量的变量包括内脏脂肪组织（VAT）、皮下脂肪组织（SAT）、VAT 密度（VAT-D）和 SAT 密度（SAT-D）。我们还根据患者是否患有 2 型糖尿病（T2DM）检查了参数。LSG 诱导 BW、SAT 和 VAT 在 LSG 后显著减少。此外，SAT-D 和 VAT-D 均增加，空腹血糖（FPG）和 HbA1c 降低，但 C 肽不降低。手术后 ΔSAT 和 ΔVAT 呈正相关，ΔSAT-D 和 ΔVAT-D 与 ΔBW 和/或 FPG 呈负相关。此外，多元回归模型显示，总 BW 损失（TBWL）与 ΔSAT（β=0.84；p<0.001）和 ΔVAT-D（β=-0.45；p<0.05）密切相关，FPG 的改善与 ΔVAT（β=0.61；p<0.05）有关LSG 后。最后，16 例 T2DM 患者中 ΔFPG 与 ΔVAT 相关（r=0.58；p<0.05），而非 T2DM 患者中则不相关。TBWL 与 ΔSAT 和 ΔVAT-D 相关，FPG 的改善与 LSG 后肥胖日本患者的 ΔVAT 相关。
