Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine, Oita University, Yufu City 879-5593, Japan.
Obesity and Diabetes Center for Advanced Medicine, Faculty of Medicine, Oita University, Yufu City 879-5593, Japan.
Nutrients. 2024 Nov 18;16(22):3926. doi: 10.3390/nu16223926.
We analyzed the changes in obesity, glucose metabolism, and body composition over a 3-year period in Japanese patients with obesity following laparoscopic sleeve gastrectomy (LSG).
Body weight, parameters related to diabetes such as glycated hemoglobin (HbA1c), and electrical impedance analysis were used to assess body composition in forty-eight Japanese patients with obesity before surgery and 6 months, 1 year, 2 years, and 3 years after LSG.
At 6 months, 1, 2, and 3 years post-LSG, there were significant reductions in body weight, body mass index, blood pressure, fasting plasma glucose, triglyceride, and HbA1c levels. Six months after LSG, fat mass (FM), muscle mass (MM), and %FM all showed a decrease compared to pre-treatment values (all < 0.05). FM and %FM remained in a decreased state until 3 years had passed. In contrast, %MM increased at 6 months post-LSG and was maintained up to 3 years post-LSG (all < 0.05). Furthermore, changes in FM and %FM were associated with changes in body weight and A1C. In contrast, change in %MM exhibited a negative correlation with body weight and A1C following LSG. Finally, multivariate regression analyses demonstrated that alterations in FM were independent factors affecting body weight in patients with obesity 3 years after LSG.
We observed improvements in FM, fasting plasma glucose, and HbA1c levels over a 3-year period in Japanese patients after LSG. The reduction in FM and maintenance of %MM after LSG were suggested as possible links between the effects of LSG on obesity and diabetes over 3 years.
我们分析了肥胖、葡萄糖代谢和身体成分在日本肥胖患者接受腹腔镜袖状胃切除术（LSG）后 3 年内的变化。
在手术前和 LSG 后 6 个月、1 年、2 年和 3 年，使用体重、与糖尿病相关的参数（如糖化血红蛋白[HbA1c]）和电阻抗分析来评估 48 例日本肥胖患者的身体成分。
LSG 后 6 个月、1 年、2 年和 3 年，体重、体重指数、血压、空腹血糖、甘油三酯和 HbA1c 水平均显著降低。LSG 后 6 个月，与治疗前相比，脂肪量（FM）、肌肉量（MM）和 %FM 均降低（均 < 0.05）。FM 和 %FM 一直处于下降状态，直到 3 年。相比之下，%MM 在 LSG 后 6 个月增加，并维持至 LSG 后 3 年（均 < 0.05）。此外，FM 和 %FM 的变化与体重和 A1C 的变化相关。相比之下，LSG 后，%MM 的变化与体重和 A1C 呈负相关。最后，多元回归分析表明，FM 的改变是肥胖患者 LSG 3 年后体重的独立影响因素。
我们观察到日本肥胖患者 LSG 后 3 年内 FM、空腹血糖和 HbA1c 水平得到改善。LSG 后 FM 的减少和 %MM 的维持可能是 LSG 对肥胖和糖尿病影响 3 年的关联因素。
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