Razek Ahmed Abdel, El-Hadidy El-Hadidy Mohamed, Moawad Mohamed El-Said, El-Metwaly Nader, El-Said Amr Abd El-Hamid
Mansoura University Hospital, Mansoura, Egypt.
Pol J Radiol. 2019 Mar 8;84:e142-e146. doi: 10.5114/pjr.2019.84096. eCollection 2019.
To assess the lacrimal glands in patients with thyroid eye disease with diffusion-weighted magnetic resonance (MR) imaging.
This study was carried out on 44 consecutive patients (17 males, 27 females, with mean age 36 years) with thyroid eye disease and 20 age- and sex-matched volunteers. They underwent diffusion-weighted MR imaging of the orbit. The apparent diffusion coefficient (ADC) values of the lacrimal glands were calculated and correlated with the clinical activity score (CAS).
The mean ADC of lacrimal glands in thyroid eye disease (1.73 × 10 mm/s) was significantly higher ( = 0.001) than that of volunteers (1.52 × 10 mm/s). The cutoff ADC value of lacrimal gland used for differentiation of thyroid eye disease from volunteers was 1.62 × 10 mm/s with an area under the curve value of 0.95 and an accuracy of 96%. There was significant difference ( = 0.03) in the ADC of the lacrimal glands in patients with active ( = 24) and inactive ( = 20) disease. The cutoff ADC value of the lacrimal gland used to suspect active disease was 1.76 × 10 mm/s with an area under the curve value of 0.80 and an accuracy of 82%. There was positive correlation between the ADC value of the lacrimal glands and CAS ( = 0.73, = 0.001).
The ADC of the lacrimal glands is a non-invasive imaging parameter that can be used for diagnosis of thyroid eye disease and to predict the active form of the disease.
通过扩散加权磁共振成像评估甲状腺眼病患者的泪腺。
本研究对44例连续的甲状腺眼病患者（17例男性，27例女性，平均年龄36岁）以及20名年龄和性别匹配的志愿者进行。他们接受了眼眶的扩散加权磁共振成像检查。计算泪腺的表观扩散系数（ADC）值，并将其与临床活动评分（CAS）相关联。
甲状腺眼病患者泪腺的平均ADC值（1.73×10⁻³mm²/s）显著高于志愿者（1.52×10⁻³mm²/s）（P = 0.001）。用于区分甲状腺眼病患者与志愿者的泪腺ADC临界值为1.62×10⁻³mm²/s，曲线下面积值为0.95，准确率为96%。活动期（n = 24）和非活动期（n = 20）疾病患者的泪腺ADC存在显著差异（P = 0.03）。用于怀疑活动期疾病的泪腺ADC临界值为1.76×10⁻³mm²/s，曲线下面积值为0.80，准确率为82%。泪腺ADC值与CAS之间存在正相关（r = 0.73，P = 0.001）。
泪腺的ADC是一种可用于诊断甲状腺眼病并预测疾病活动形式的非侵入性成像参数。
