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大剂量鞘内注射二醋吗啡在腹腔镜减肥手术中的应用:一项单中心回顾性队列研究。

The use of high-dose intrathecal diamorphine in laparoscopic bariatric surgery: a single-centre retrospective cohort study.

作者信息

Wojcikiewicz Thomas G, Jeans John, Karmali Anil, Nkhoma Jackline, Cousins Jonathan, Kynoch Michael

机构信息

Department of Anaesthesia, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.

出版信息

Br J Pain. 2019 May;13(2):106-111. doi: 10.1177/2049463718800521. Epub 2018 Sep 19.

Abstract

INTRODUCTION

The use of intrathecal diamorphine is not commonplace in laparoscopic bariatric surgery. At our institution, a major UK bariatric centre, high-dose intrathecal diamorphine is routinely utilised.

METHODS

Data were analysed retrospectively. Fifty-three patients who had a spinal anaesthetic were matched against age, sex, body mass index and surgical procedure type to generate controls. Pain scores were recorded in the post-anaesthetic care unit on arrival, after 1 hour and on discharge to the ward. Post-operative nausea and vomiting; post-operative hypertension; pruritus; 24-hour morphine consumption and length of stay were measured.

RESULTS

Pain scores were better in the spinal anaesthetic group in all measured categories (p = 0.033, p < 0.01, p < 0.01); post-operative nausea and vomiting was less common in the spinal anaesthetic group (p < 0.01); post-operative hypertension was less common in the spinal anaesthetic group (p = 0.25); pruritus was more common in the spinal anaesthetic group (p < 0.01); morphine consumption was less common in the spinal anaesthetic group (p = 0.037). Length of hospital stay was reduced by 12.4 hours (p = 0.025).

CONCLUSION

We propose that this is a practical and safe technique to adopt. A randomised-control trial will need to be conducted in order to find the most efficacious volume of local anaesthetic and dose of diamorphine.

摘要

引言

鞘内注射二醋吗啡在腹腔镜减肥手术中并不常见。在我们机构,一家英国主要的减肥中心,常规使用高剂量鞘内注射二醋吗啡。

方法

对数据进行回顾性分析。将53例接受脊髓麻醉的患者与年龄、性别、体重指数和手术类型相匹配以生成对照组。在麻醉后护理单元记录患者到达时、1小时后和转至病房时的疼痛评分。测量术后恶心和呕吐、术后高血压、瘙痒、24小时吗啡消耗量和住院时间。

结果

在所有测量类别中,脊髓麻醉组的疼痛评分更好(p = 0.033,p < 0.01,p < 0.01);脊髓麻醉组术后恶心和呕吐较少见(p < 0.01);脊髓麻醉组术后高血压较少见(p = 0.25);脊髓麻醉组瘙痒更常见(p < 0.01);脊髓麻醉组吗啡消耗量较少见(p = 0.037)。住院时间缩短了12.4小时(p = 0.025)。

结论

我们认为这是一种实用且安全的技术。需要进行一项随机对照试验,以确定局部麻醉剂的最有效用量和二醋吗啡的剂量。

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