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一项前瞻性观察研究:腹腔镜减重手术中高剂量鞘内吗啡的应用:单中心经验。

A Prospective Observational Study of High-Dose Intrathecal Diamorphine in Laparoscopic Bariatric Surgery: a Single-Centre Experience.

机构信息

St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.

出版信息

Obes Surg. 2020 May;30(5):1814-1819. doi: 10.1007/s11695-020-04384-9.

Abstract

BACKGROUND

Post-operative pain management following laparoscopic bariatric surgery can be challenging. There are concerns regarding the use of opioids. The rate of cardiorespiratory problems following neuraxial opioids is unclear. There is little published data on their use in bariatric surgery. This study aimed to assess technique feasibility, pain outcomes, patient acceptability, and the side effects and complications of a 'high-dose' (1.0 mg) intrathecal diamorphine technique for patients undergoing primary laparoscopic bariatric surgery.

MATERIALS AND METHODS

Fifty patients were included. Eleven patients (22%) had a diagnosis of OSA. All patients had a spinal anaesthetic with 2.0 mL of 0.25% isobaric bupivacaine containing 1.0 mg diamorphine. General anaesthesia followed together with multi-modal analgesia and anti-emesis. Post-operative pain scores, complications, and side effects in the first 24 h post-operative period were documented. Patients were followed up 6 to 8 weeks after discharge.

RESULTS

All patients had a working spinal anaesthetic with thirty-nine insertions (78%) on the first attempt. Pain scores were similar to previously published data where they were found to be superior to a non-spinal analgesic regime. The median 24 h post-operative oral morphine equivalent consumption was 5 mg. Eight patients (16%) required urinary catheterisation. Four patients (8%) complained of pruritus. Eighteen patients (36%) had post-operative nausea or vomiting. Thirty-three patients (66%) responded to the follow-up request. Thirty of the thirty-three patients (91%) stated they would have the spinal anaesthetic again.

CONCLUSION

We have demonstrated that neuraxial blockade is a simple, practical, and feasible technique to adopt. Our case series demonstrated a high level of patient acceptability.

摘要

背景

腹腔镜减重手术后的疼痛管理具有挑战性。人们对阿片类药物的使用存在担忧。椎管内阿片类药物使用后发生心肺问题的发生率尚不清楚。关于其在减重手术中的应用,发表的数据很少。本研究旨在评估一种“高剂量”(1.0mg)鞘内吗啡技术用于行腹腔镜减重手术患者的技术可行性、疼痛结局、患者接受度,以及其副作用和并发症。

材料和方法

共纳入 50 例患者。11 例(22%)患者诊断为 OSA。所有患者均行脊髓麻醉,使用 2.0mL0.25%等比重布比卡因,其中含有 1.0mg 吗啡。全身麻醉后联合多模式镇痛和止吐治疗。记录术后 24 小时内的疼痛评分、并发症和副作用。患者在出院后 6 至 8 周时进行随访。

结果

所有患者均成功实施了脊髓麻醉,39 例(78%)为首次尝试。疼痛评分与先前发表的数据相似,发现优于非脊髓镇痛方案。术后 24 小时内口服吗啡等效物的中位数消耗量为 5mg。8 例(16%)患者需要导尿。4 例(8%)患者出现瘙痒。18 例(36%)患者出现术后恶心或呕吐。33 例(66%)患者回复了随访请求。33 例患者中的 30 例(91%)表示他们将再次接受脊髓麻醉。

结论

我们已经证明,椎管内阻滞是一种简单、实用且可行的技术。我们的病例系列研究表明,患者接受度很高。

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