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原发性心脏淋巴瘤罕见病例及早期手术减瘤的作用:一例报告

A rare case of primary cardiac lymphoma and the role of early surgical debulking: a case report.

作者信息

Grantomo Jonathan, Pratita Jenni, Rachmat Jusuf, Saraswati Meilania

机构信息

Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Salemba Raya No.6, Jakarta Pusat, DKI Jakarta, Indonesia.

Thoracic and Cardiovascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Salemba Raya No.6, Jakarta Pusat, DKI Jakarta, Indonesia.

出版信息

Eur Heart J Case Rep. 2018 Oct 23;2(4):yty116. doi: 10.1093/ehjcr/yty116. eCollection 2018 Dec.

Abstract

BACKGROUND

Primary cardiac lymphoma (PCL) is a very rare disease and is most commonly found among immunocompromised patients. Its cardiac manifestations are non-specific, leading to delayed diagnosis and poor prognosis. However, chemotherapy could improve survival, which makes early and prompt diagnosis very crucial. This is a report of a rare case of PCL found on a 73-year-old man who benefit from early debulking surgery.

CASE SUMMARY

A 73-year-old man presented with worsening dyspnoea over the last 2 months. A 7.2 × 10.2 cm intramural tumour was found extending from the right atrium to the right ventricle. It was considered that the tumour could cause sudden death due to its size and extension. Therefore, surgical debulking with biopsy and valve repair was done. Cytology examination from the resected specimen demonstrated diffuse large B-cell lymphoma non-germinal centre B-cell like type. He was discharged 2 weeks after the surgery in stable condition and referred to internal medicine department for chemotherapy. However, he chose palliative home care and died 44 days after surgery.

DISCUSSION

In cases of PCL with concerning tumour size and symptoms due to cardiac obstruction, early surgical debulking could improve haemodynamics, prevent sudden death, and confirm immunopathological diagnosis needed in determining further chemotherapy, which is proven to improve survival.

摘要

背景

原发性心脏淋巴瘤(PCL)是一种非常罕见的疾病,最常见于免疫功能低下的患者。其心脏表现不具有特异性,导致诊断延迟且预后不良。然而,化疗可以提高生存率,这使得早期及时诊断至关重要。本文报告了一例在一名73岁男性中发现的罕见PCL病例,该患者受益于早期减瘤手术。

病例摘要

一名73岁男性在过去2个月中出现呼吸困难加重。发现一个7.2×10.2厘米的壁内肿瘤,从右心房延伸至右心室。考虑到肿瘤的大小和范围,认为其可能导致猝死。因此,进行了减瘤手术、活检及瓣膜修复。切除标本的细胞学检查显示为弥漫性大B细胞淋巴瘤,非生发中心B细胞样类型。术后2周患者出院,病情稳定,并转诊至内科进行化疗。然而,他选择了姑息性家庭护理,并在术后44天死亡。

讨论

对于因心脏梗阻导致肿瘤大小和症状令人担忧的PCL病例,早期手术减瘤可改善血流动力学、预防猝死,并确认确定进一步化疗所需的免疫病理诊断,这已被证明可提高生存率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67e0/6425998/4f6efdef8f11/yty116f1.jpg

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