Oezpeker Ulvi Cenk, Feuchtner Gudrun, Bonaros Nikolaos
University Clinic of Cardiac Surgery, Medical University of Innsbruck, Anichstrasse 35, Innsbruck, Austria.
University Clinic of Radiology, Medical University of Innsbruck, Anichstrasse 35, Innsbruck, Austria.
Eur Heart J Case Rep. 2018 Dec 7;2(4):yty117. doi: 10.1093/ehjcr/yty117. eCollection 2018 Dec.
Surgical implantation rates of bioprosthetic valves, especially the use of sutureless or rapid deployment valves, as well as the advent of transcatheter valve implantation (TAVR) have increased during the last decades mainly due to their excellent haemodynamic and clinical results. One common characteristic of all bioprosthetic types of surgical aortic valve replacement (SAVR) and TAVR is the risk of early degeneration, which leads to valve-dysfunction and is associated with higher rates of valve reinterventions. Recent studies have demonstrated that cusp thrombosis may play a role in early valve dysfunction. This case report is, to our knowledge, the first documentation on a successful treatment of early aortic valve (AV) degeneration of a sutureless AV thrombosis with a valve-in-valve (ViV) TAVR implantation.
A 77 years old woman was re-evaluated from the heart-team, which considered the following characteristics: severe impairment of mobility and frailty with an STS-score of 10.01% and a EuroSCORE II of 6.9%. Due to the high surgical risk for SAVR, we decided to perform a ViV-TAVR using a balloonexpandable bioprosthesis. The procedure was performed via transfemoral access under general anaesthesia using a 23 mm Edwards-Sapien 3 bioprosthesis without balloon-valvuloplasty and with nominal-volume dilation under rapid-pacing.
The differentiation of bioprosthesis valve thrombosis, and hypoattenuating leaflet thickening vs. structural valve degeneration can be difficult, and a multimodality imaging approach, comprising trans-thoracic echocardiogram, transoesophageal echocardiography and computed tomography, useful. These investigations are very important to decide the right strategy of surgical valve replacement vs. TAVR.
在过去几十年中,生物瓣膜的手术植入率,尤其是无缝合或快速植入瓣膜的使用,以及经导管瓣膜植入术(TAVR)的出现有所增加,这主要归功于它们出色的血流动力学和临床效果。所有生物瓣膜类型的外科主动脉瓣置换术(SAVR)和TAVR的一个共同特征是早期退变风险,这会导致瓣膜功能障碍,并与更高的瓣膜再次干预率相关。最近的研究表明,瓣叶血栓形成可能在早期瓣膜功能障碍中起作用。据我们所知,本病例报告是首例关于采用瓣中瓣(ViV)TAVR植入术成功治疗无缝合主动脉瓣血栓形成所致早期主动脉瓣(AV)退变的记录。
一名77岁女性由心脏团队重新评估,该团队考虑了以下特征:行动严重受限且身体虚弱,STS评分10.01%,欧洲心脏手术风险评估系统(EuroSCORE)II为6.9%。由于SAVR的手术风险高,我们决定使用球囊扩张式生物瓣膜进行ViV-TAVR。该手术在全身麻醉下经股动脉入路进行,使用23mm爱德华兹-赛沛3生物瓣膜,未进行球囊瓣膜成形术,在快速起搏下进行标称容量扩张。
生物瓣膜血栓形成、瓣叶低密度增厚与结构性瓣膜退变的鉴别可能具有挑战性,采用包括经胸超声心动图、经食管超声心动图和计算机断层扫描的多模态成像方法会很有用。这些检查对于决定外科瓣膜置换与TAVR的正确策略非常重要。