Liu Rui-Hua, Shan Qi-Chao, Hu Xu-Hong, Loh Teck-Peng
Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.
Chem Commun (Camb). 2019 May 7;55(38):5519-5522. doi: 10.1039/c9cc01715a.
Synthetically versatile anthranils as a bifunctional amino source have been employed for the first time to enable direct amination on unactivated C(sp3)-H bonds of thioamides under Cp*CoIII catalysis. The excellent site-selectivity on primary C(sp3)-H bonds is observed for a diverse array of thioamides with high functional group tolerance. Further applicability of the products is also highlighted through a series of interesting synthetic elaborations.
作为双功能氨基源的合成用途广泛的邻氨基苯甲酸首次被用于在Cp*CoIII催化下实现硫代酰胺未活化C(sp3)-H键的直接胺化反应。对于各种各样具有高官能团耐受性的硫代酰胺，观察到在伯C(sp3)-H键上具有出色的位点选择性。通过一系列有趣的合成转化，还突出了产物的进一步适用性。
