Ivanov S, Gavazova E, Chelibonova-Lorer H
Cancer Biochem Biophys. 1986 Dec;9(1):41-51.
The multiple forms of galactosyltransferase in chicken serum and in microsomal and plasma membrane preparations from liver and viral induced hepatoma Mc-29 have been studied by isoelectric focussing. An elevation of the hepatoma plasma membrane enzyme activity was described and in the pattern of the multiple forms of the enzyme two forms were found (pI-5.34 and 8.22) which were similar to those described in the serum of hepatoma bearing chickens (pI-5.36 and 8.24). A conclusion is drawn that these enzyme forms are apparently present to a greater extent in the hepatoma plasma membrane enriched fractions than in liver membranes and are probably shed into the serum of the tumor bearing animals.
利用等电聚焦法研究了鸡血清以及肝脏和病毒诱导的肝癌Mc-29的微粒体与质膜制剂中的多种形式的半乳糖基转移酶。已报道肝癌质膜酶活性升高，并且在该酶多种形式的图谱中发现了两种形式（pI-5.34和8.22），它们与患肝癌鸡血清中描述的形式（pI-5.36和8.24）相似。得出的结论是，这些酶形式在富含肝癌质膜的组分中显然比在肝细胞膜中含量更高，并且可能脱落到荷瘤动物的血清中。
