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异环磷酰胺治疗晚期胰腺癌:5年经验

Ifosfamide in advanced pancreatic cancer. A 5-year experience.

作者信息

Gad-el-Mawla N

出版信息

Cancer Chemother Pharmacol. 1986;18 Suppl 2:S55-6. doi: 10.1007/BF00647453.

DOI:10.1007/BF00647453
PMID:3102092
Abstract

Ifosfamide was studied in advanced pancreatic tumor at the National Cancer Institute, Cairo. Over five years, 25 patients received a daily dose of 1.8 g ifosfamide for five days, courses reported every 21 days. Complete remission was achieved in 1 patient and partial remission in 14 patients, an overall result of 60%, average duration of response being 12+ months. Mesna was used for uroprotection.

摘要

开罗国家癌症研究所对晚期胰腺肿瘤患者使用异环磷酰胺进行了研究。在五年时间里,25名患者连续五天每日接受1.8克异环磷酰胺治疗,每21天为一个疗程。1例患者实现完全缓解,14例患者部分缓解,总体缓解率为60%,平均缓解持续时间为12个月以上。使用美司钠进行尿路保护。

相似文献

1
Ifosfamide in advanced pancreatic cancer. A 5-year experience.异环磷酰胺治疗晚期胰腺癌:5年经验
Cancer Chemother Pharmacol. 1986;18 Suppl 2:S55-6. doi: 10.1007/BF00647453.
2
Ifosfamide is an inactive substance in the treatment of pancreatic carcinoma. The Gastrointestinal Tumor Study Group.异环磷酰胺在胰腺癌治疗中是一种无活性物质。胃肠道肿瘤研究组。
Cancer. 1989 Nov 15;64(10):2010-3. doi: 10.1002/1097-0142(19891115)64:10<2010::aid-cncr2820641007>3.0.co;2-o.
3
Continuous 5-day infusion of ifosfamide with mesna in inoperable pancreatic cancer patients: a phase II study.对无法手术的胰腺癌患者连续5天输注异环磷酰胺并联合美司钠:一项II期研究。
J Cancer Res Clin Oncol. 1991;117 Suppl 4(Suppl 4):S135-8. doi: 10.1007/BF01613218.
4
Ifosfamide and mesna: marginally active in patients with advanced carcinoma of the pancreas.异环磷酰胺和美司钠:对晚期胰腺癌患者的疗效微乎其微。
J Clin Oncol. 1988 Nov;6(11):1703-7. doi: 10.1200/JCO.1988.6.11.1703.
5
Phase II experience with ifosfamide/mesna in gynecologic malignancies: preliminary report of Gynecologic Oncology Group studies.异环磷酰胺/美司钠治疗妇科恶性肿瘤的II期经验:妇科肿瘤学组研究的初步报告
Semin Oncol. 1989 Feb;16(1 Suppl 3):68-72.
6
Ifosfamide and mesna for the treatment of advanced squamous cell head and neck cancer. A GETLAC study.
Oncology. 1991;48(2):89-92. doi: 10.1159/000226902.
7
Ifosfamide/etoposide and mesna uroprotection in advanced breast cancer.
Cancer Chemother Pharmacol. 1990;26 Suppl:S87-90. doi: 10.1007/BF00685431.
8
[Ifosfamide chemotherapy ineffective for advanced pancreatic carcinoma].[异环磷酰胺化疗对晚期胰腺癌无效]
Gan To Kagaku Ryoho. 1997 Mar;24(5):569-72.
9
High-dose ifosfamide and mesna in advanced breast cancer. A phase II study.高剂量异环磷酰胺与美司钠治疗晚期乳腺癌:一项II期研究
Cancer Chemother Pharmacol. 1990;26 Suppl:S91-2. doi: 10.1007/BF00685432.
10
Phase II study of ifosfamide and mesna in refractory adenocarcinoma of the endometrium. A Gynecologic Oncology Group study.
Cancer. 1994 Mar 1;73(5):1453-5. doi: 10.1002/1097-0142(19940301)73:5<1453::aid-cncr2820730521>3.0.co;2-x.

引用本文的文献

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Long-Term Survival of Cellulose Sulphate-Encapsulated Cells and Metronomic Ifosfamide Control Tumour Growth in Pancreatic Cancer Models-A Prelude to Treating Solid Tumours Effectively in Pets and Humans.硫酸纤维素包封细胞的长期存活及小剂量节拍式异环磷酰胺对胰腺癌模型肿瘤生长的控制——有效治疗宠物和人类实体瘤的前奏
Life (Basel). 2023 Dec 18;13(12):2357. doi: 10.3390/life13122357.
2
Encapsulated cells expressing a chemotherapeutic activating enzyme allow the targeting of subtoxic chemotherapy and are safe and efficacious: data from two clinical trials in pancreatic cancer.表达化疗激活酶的囊封细胞可使亚毒性化疗药物靶向化,且安全有效:来自胰腺癌两项临床试验的数据。
Pharmaceutics. 2014 Aug 11;6(3):447-66. doi: 10.3390/pharmaceutics6030447.
3

本文引用的文献

1
The integration of chemotherapy into a combined modality approach for cancer treatment. VI. Pancreatic adenocarcinoma.化疗在癌症综合治疗模式中的应用。VI. 胰腺腺癌。
Cancer Treat Rev. 1975 Sep;2(3):193-214. doi: 10.1016/s0305-7372(75)80003-x.
Evaluation of a gene-directed enzyme-product therapy (GDEPT) in human pancreatic tumor cells and their use as in vivo models for pancreatic cancer.评价基因定向酶产物疗法(GDEPT)在人胰腺肿瘤细胞中的作用及其作为胰腺癌体内模型的用途。
PLoS One. 2012;7(7):e40611. doi: 10.1371/journal.pone.0040611. Epub 2012 Jul 16.
4
Ifosfamide treatment as a 10-day continuous intravenous infusion.异环磷酰胺采用为期10天的持续静脉输注治疗。
J Cancer Res Clin Oncol. 1995;121(5):297-302. doi: 10.1007/BF01209597.
5
Ifosfamide and mesna in the treatment of malignant disease mesna as urothelial protector.异环磷酰胺与美司钠用于恶性疾病治疗:美司钠作为尿路保护剂。
Invest New Drugs. 1989 Jul;7(2-3):261-7. doi: 10.1007/BF00170871.
6
Continuous 5-day infusion of ifosfamide with mesna in inoperable pancreatic cancer patients: a phase II study.对无法手术的胰腺癌患者连续5天输注异环磷酰胺并联合美司钠:一项II期研究。
J Cancer Res Clin Oncol. 1991;117 Suppl 4(Suppl 4):S135-8. doi: 10.1007/BF01613218.
7
Ifosfamide/mesna. A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer.异环磷酰胺/美司钠。关于其抗肿瘤活性、药代动力学特性及在癌症治疗中疗效的综述。
Drugs. 1991 Sep;42(3):428-67. doi: 10.2165/00003495-199142030-00006.