Jackson M, Warrington E K, Roe C J, Baker L R
Clin Nephrol. 1987 Jan;27(1):26-30.
Cognitive function was assessed in two groups of hemodialysis patients exposed to relatively low concentrations of aluminum in source water used to manufacture dialysate. One group of patients (long-term group) had been on dialysis for 5 years or more, the other (short-term group) for less than 5 years. Group comparison showed no significant differences of any cognitive measure. However, calculating an index of deterioration based on the discrepancy between current reading skills and current performance on the Wechsler Adult Intelligence Scale, five patients in the long-term group and two in the short-term group could be identified as functioning below their predicted premorbid optimum level. There was no correlation between cumulative exposure to water-born aluminum and any of the measures of cognitive function in either of the groups. There was a statistically significant negative correlation between the cumulative amount of aluminum prescribed to be taken orally and performance on cognitive tests in the long-term group. This observation strengthens the case for minimizing the prescription of aluminum-containing gut phosphate binders.
对两组使用用于制造透析液的源水中相对低浓度铝的血液透析患者进行了认知功能评估。一组患者（长期组）已接受透析5年或更长时间，另一组（短期组）则少于5年。组间比较显示，任何认知指标均无显著差异。然而，根据当前阅读技能与韦氏成人智力量表当前表现之间的差异计算恶化指数，长期组中有5名患者、短期组中有2名患者的功能低于其预测的病前最佳水平。两组中，水中铝的累积暴露量与任何认知功能指标之间均无相关性。在长期组中，口服铝的累积量与认知测试表现之间存在统计学上显著的负相关。这一观察结果进一步证明了应尽量减少含铝肠道磷酸盐结合剂处方的理由。
