Neefe J R, Phillips E A, Treat J
Diagn Immunol. 1986;4(6):299-305.
Thirty-two melanoma patients treated with lymphoblastoid alpha interferon (Wellferon) were studied for augmentation of five putative parameters of natural immunity including natural killing (NK), antibody-dependent cellular cytotoxicity (ADCC), cell-mediated inhibition of growth in culture of a murine tumor (GIA), and the size of the OKTIO+ and Leu 7+ subpopulations of peripheral blood mononuclear cells (OKTIO and Leu7). This study confirms and extends our previous conclusions that interferon increases GIA and OKTIO. The increases occurred at 24 hr after interferon, both early and late in the course of treatment, and were dose dependent. NK, ADCC, and Leu7 were activated in many patients individually and mean values for NK and Leu7 were increased in the population as a whole. Two patients with complete remission showed dramatically increased natural immunity by the parameters studied, but the pattern of increase was very different for each patient. The current study of lymphoblastoid alpha interferon demonstrates the immunomodulatory potential of interferon given to melanoma patients, but it fails to support the hypothesis that augmentation of these parameters of natural immunity by interferon may result in tumor responses.
对32例接受淋巴母细胞α干扰素（Wellferon）治疗的黑色素瘤患者进行了研究，以评估包括自然杀伤（NK）、抗体依赖性细胞毒性（ADCC）、细胞介导的对小鼠肿瘤培养物生长的抑制作用（GIA）以及外周血单个核细胞的OKT10+和Leu 7+亚群（OKT10和Leu7）大小在内的五个假定自然免疫参数的增强情况。本研究证实并扩展了我们之前的结论，即干扰素可增加GIA和OKT10。这种增加在干扰素注射后24小时出现，在治疗过程的早期和晚期均有发生，且呈剂量依赖性。许多患者的NK、ADCC和Leu7分别被激活，总体人群中NK和Leu7的平均值有所增加。两名完全缓解的患者在所研究的参数方面显示出自然免疫显著增强，但每位患者的增加模式非常不同。目前对淋巴母细胞α干扰素的研究证明了给予黑色素瘤患者干扰素的免疫调节潜力，但未能支持干扰素增强这些自然免疫参数可能导致肿瘤反应的假设。
