使用 N-卤代琥珀酰亚胺和 PhSSiMe 或 PhSSPh 进行芳卤化反应。
Aromatic Halogenation Using N-Halosuccinimide and PhSSiMe or PhSSPh.
机构信息
School of Pharmaceutical Sciences , Kindai University , Higashi-Osaka , Osaka 577-8502 , Japan.
出版信息
J Org Chem. 2019 Jun 7;84(11):7405-7410. doi: 10.1021/acs.joc.9b00817. Epub 2019 May 9.
We developed a mild aromatic halogenation reaction using a combination of N-halosuccinimide and PhSSiMe or PhSSPh. Less reactive aromatic compounds, such as methyl 4-methoxybenzoate, were brominated with PhSSiMe or PhSSPh and N-bromosuccinimide in high yields. No reaction was observed in the absence of PhSSiMe or PhSSPh. This method is also applicable to chlorination reactions using N-chlorosuccinimide and PhSSPh.
我们开发了一种温和的芳香族卤化反应，使用 N-卤代琥珀酰亚胺和 PhSSiMe 或 PhSSPh 的组合。反应活性较低的芳香族化合物，如 4-甲氧基苯甲酸甲酯，与 PhSSiMe 或 PhSSPh 和 N-溴代琥珀酰亚胺反应，可以高产率得到溴化产物。如果没有 PhSSiMe 或 PhSSPh，就不会发生反应。该方法也适用于使用 N-氯代琥珀酰亚胺和 PhSSPh 的氯化反应。
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