N-卤代琥珀酰亚胺对杀结核菌素的卤化反应。通向5-溴杀结核菌素的直接途径，5-溴杀结核菌素是真核细胞中RNA合成的可逆抑制剂。
Halogenation of tubercidin by N-halosuccinimides. A direct route to 5-bromotubercidin, a reversible inhibitor of RNA synthesis in eukaryotic cells.
作者信息
Bergstrom D E, Brattesani A J
出版信息
Nucleic Acids Res. 1980 Dec 20;8(24):6213-9. doi: 10.1093/nar/8.24.6213.
Abstract
Tubercidin may be directly brominated by reaction with N-bromosuccinimide in DMF to give 5-bromotubercidin, a reversible inhibitor of RNA synthesis. When buffered with potassium acetate the major product is 6-bromotubercidin. 5,6-Dibromotubercidin is formed in minor amounts under both conditions. N-Chlorosuccinimide and tubercidin give 5-chlorotubercidin and 5,6-dichlorotubercidin.
摘要
杀结核菌素可通过在N,N-二甲基甲酰胺中与N-溴代琥珀酰亚胺反应直接进行溴化，生成5-溴杀结核菌素，它是一种RNA合成的可逆抑制剂。当用乙酸钾缓冲时，主要产物是6-溴杀结核菌素。在这两种条件下，5,6-二溴杀结核菌素的生成量都较少。N-氯代琥珀酰亚胺与杀结核菌素反应生成5-氯杀结核菌素和5,6-二氯杀结核菌素。
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