Diehl Christian D, Halasz Lia M, Wilkens Jan J, Grosu Anca-Ligia, Combs Stephanie E
Technichal University of Munich (TUM), Klinikum rechts der Isar, Department of Radiation Oncology, München, Germany.
Helmholtz Zentrum München (HMGU), Institute of Innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Neuherberg Germany.
Top Magn Reson Imaging. 2019 Apr;28(2):49-61. doi: 10.1097/RMR.0000000000000197.
Radiation therapy (RT) is a mainstay in the interdisciplinary treatment of brain tumors of the skull base and brain. Technical innovations during the past 2 decades have allowed for increasingly precise treatment with better sparing of adjacent healthy tissues to prevent treatment-related side effects that influence patients' quality of life. Particle therapy with protons and charged ions offer favorable kinetics with sharp dose deposition in a well-defined depth (Bragg-Peak) and a steep radiation fall-off beyond that maximum. This review highlights the role of particle therapy in the management of primary brain tumors and tumors of the skull base.
放射治疗（RT）是颅底和脑部脑肿瘤多学科治疗的主要手段。过去20年中的技术创新使治疗越来越精确，能更好地保护相邻健康组织，以预防影响患者生活质量的治疗相关副作用。质子和带电离子粒子疗法具有良好的剂量学特性，在明确的深度（布拉格峰）有尖锐的剂量沉积，且在该最大值之外辐射剂量急剧下降。本综述重点介绍了粒子疗法在原发性脑肿瘤和颅底肿瘤治疗中的作用。
