Maheux R, Lemay A, Merat P
Fertil Steril. 1987 Feb;47(2):229-33.
Nine women harboring uterine leiomyomas have been treated with subcutaneous injections and then with intranasal insufflation of luteinizing hormone-releasing hormone agonist for a total treatment period of 6 months. After initial stimulation, mean serum estradiol progressively decreased and stabilized at 36.8 +/- 4.9 pg/ml for the rest of the treatment period. The volume of uterine leiomyomas has been reduced by an average of 71%. Side effects and hot flushes were less severe and better tolerated than reported after sole subcutaneous administration.
九名患有子宫平滑肌瘤的女性接受了皮下注射，然后进行了促黄体生成素释放激素激动剂的鼻内吹入，总治疗期为6个月。在初始刺激后，平均血清雌二醇逐渐下降，并在治疗期的剩余时间稳定在36.8 +/- 4.9 pg/ml。子宫平滑肌瘤的体积平均减少了71%。与单独皮下给药后报告的情况相比，副作用和潮热症状较轻，耐受性更好。
