Yumusak N, Sadic M, Akbulut A, Aydinbelge F N, Koca G, Korkmaz M
Bratisl Lek Listy. 2019;120(4):263-269. doi: 10.4149/BLL_2019_048.
The aim of the present study was to investigate the radioprotective effect of vitamin E in the prevention of radioiodine (RAI) induced gastrointestinal damage.
Twenty-four rats were randomly divided into three groups as follows: Group-1 was untreated control group, Group-2 was orally administered single dose of 111 MBq RAI, and Group-3 was orally administered 111 MBq RAI and 1 mL of oral vitamin E. Vitamin E was started two days before RAI administration and was continued for five days once daily after RAI. Pathomorphological parameters of gastrointestinal tissues (stomach, small intestines and bowels) were measured using Hematoxylin-Eosin and Masson's trichrome staining.
Varying degrees of inflammation, edema, ulcer, mucosal degeneration, necrosis and fibrosis were seen in the stomach, small intestine and bowel tissues of the rats in both study groups and not in the control group. The differences were statistically significant between these groups for all parameters (p < 0.05). The histopathological damage in the vitamin E treated group was significantly less than the damage in the RAI only group (p < 0.05 for all pathomorphological parameters).
The results of this study showed that vitamin E has a radioprotective property with antiinflammatory and antifibrotic effects protecting against gastrointestinal damage caused by radioiodine (Tab. 3, Fig. 3, Ref. 26).
本研究旨在探讨维生素E在预防放射性碘（RAI）所致胃肠道损伤方面的辐射防护作用。
将24只大鼠随机分为三组：第一组为未处理的对照组，第二组口服单剂量111 MBq的RAI，第三组口服111 MBq的RAI及1 mL口服维生素E。维生素E在给予RAI前两天开始服用，RAI给药后每天服用一次，持续五天。使用苏木精-伊红染色和马松三色染色法测量胃肠道组织（胃、小肠和大肠）的病理形态学参数。
两个研究组大鼠的胃、小肠和大肠组织均出现不同程度的炎症、水肿、溃疡、黏膜变性、坏死和纤维化，而对照组未出现。所有参数在这些组之间的差异具有统计学意义（p < 0.05）。维生素E治疗组的组织病理学损伤明显小于仅接受RAI组（所有病理形态学参数p < 0.05）。
本研究结果表明，维生素E具有辐射防护特性，具有抗炎和抗纤维化作用，可预防放射性碘引起的胃肠道损伤（表3，图3，参考文献26）。
