雄性促性腺激素分泌调节中γ-氨基丁酸能和阿片样物质途径之间的相互作用。

Interaction between gabaergic and opioid pathways in the regulation of gonadotropin secretion in males.

作者信息

Elias A N, Kyaw T, Stone S, Weathersbee P, Iyer K, Ascher M S

出版信息

Horm Metab Res. 1986 Dec;18(12):838-41. doi: 10.1055/s-2007-1012452.

DOI:10.1055/s-2007-1012452

Abstract

The effects of naloxone infusion given together with an infusion of LRH on gonadotropin secretion, were studied in 6 normal male volunteers before and after pretreatment with the GABA-transaminase inhibitor, valproic acid. In concordance with previous studies, naloxone infusion augmented the LRH-stimulated secretion of LH. Baseline serum LH concentrations were not significantly different after valproic acid pretreatment compared to control values. Similarly, valproic acid pretreatment failed to blunt the naloxone-augmented LRH-stimulated secretion of LH. Our data suggest that the previously reported animal studies on the central suppressive effect of GABA on endogenous LRH release is less prominent than the suppressive effect of opioidergic regulatory mechanisms in the human male.

摘要

在6名正常男性志愿者中，研究了在使用γ-氨基丁酸转氨酶抑制剂丙戊酸进行预处理前后，纳洛酮输注与促黄体生成素释放激素（LRH）输注同时进行时对促性腺激素分泌的影响。与先前的研究一致，纳洛酮输注增强了LRH刺激的促黄体生成素（LH）分泌。与对照值相比，丙戊酸预处理后的基础血清LH浓度无显著差异。同样，丙戊酸预处理未能减弱纳洛酮增强的LRH刺激的LH分泌。我们的数据表明，先前报道的关于γ-氨基丁酸对人类男性内源性LRH释放的中枢抑制作用的动物研究，不如阿片样物质调节机制的抑制作用显著。