Ohmori T, Tamura K, Tsuru S, Nomoto K
Jpn J Cancer Res. 1986 Dec;77(12):1256-63.
The effects of protein-bound polysaccharide (SN-C) extracted from Cordyceps ophioglossoides on the growth of transplanted allogeneic and syngeneic murine tumors were studied. SN-C given by intraperitoneal administration suppressed the growth of sarcoma-180 transplanted subcutaneously in mice. Intraperitoneal administration of SN-C also caused a significant prolongation of the life span of ICR mice inoculated intraperitoneally with Ehrlich carcinoma, and C3H/He mice inoculated intraperitoneally with a syngeneic tumor (X-5563). SN-C showed a significant cytocidal effect on cultured tumor cells. SN-C did not affect delayed-type hypersensitivity (DTH) in normal mice, but restored the depressed capacity to raise DTH in tumor-bearing mice. These results suggested that SN-C may exert both direct and host-mediated antitumor effects.
研究了从蛇形虫草中提取的蛋白结合多糖（SN-C）对同种异体和同基因小鼠移植瘤生长的影响。腹腔注射SN-C可抑制小鼠皮下移植的肉瘤-180的生长。腹腔注射SN-C还可显著延长腹腔接种艾氏癌的ICR小鼠以及腹腔接种同基因肿瘤（X-5563）的C3H/He小鼠的寿命。SN-C对培养的肿瘤细胞具有显著的杀细胞作用。SN-C不影响正常小鼠的迟发型超敏反应（DTH），但可恢复荷瘤小鼠降低的DTH诱导能力。这些结果表明，SN-C可能发挥直接和宿主介导的抗肿瘤作用。
