Yoshikumi C, Nomoto K, Matsunaga K, Fuji T, Takeya K
Gan. 1975 Dec;66(6):649-54.
Effect of PS-K on tumor growth and antibody production was studied in inbred C57BL/6, SL, C3H/He, and AKR mice, and in colony-bred ICR mice. (1) PS-K exhibited antitumor activity on sarcoma-180 in ICR mice, but not in AKR mice. Growth of sarcoma-180 was suppressed to the intermediate extent in other strains. (2) In ICR strain, antibody production against trinitrophenyl was depressed in mice bearing sarcoma-180 and restored by PS-K. In AKR mice, on the other hand, antibody production was not depressed in tumor-bearing state and was not augmented by PS-K. Other strains showed intermediate degrees of suppression of antibody-producing capacity by sarcoma-180 and its restoration by PS-K.CR strain, the growth of Ehrlich tumor as the challenge tumor was enhanced in mice bearing sarcoma-180 as compared to that in controls. After the treatment with PS-K in this strain, however, not only the growth of sarcoma-180 but also of Ehrlich tumor was inhibited completely. On the other hand, the growth of Ehrlich tumor in AKR strain was neither enhanced in mice bearing sarcoma-180 nor inhibited by PS-K.
在近交系C57BL/6、SL、C3H/He和AKR小鼠以及群体饲养的ICR小鼠中研究了PS-K对肿瘤生长和抗体产生的影响。(1)PS-K对ICR小鼠的肉瘤-180具有抗肿瘤活性，但对AKR小鼠无此活性。在其他品系中，肉瘤-180的生长受到中度抑制。(2)在ICR品系中，携带肉瘤-180的小鼠针对三硝基苯基的抗体产生受到抑制，而PS-K可使其恢复。另一方面，在AKR小鼠中，荷瘤状态下抗体产生未受抑制，PS-K也未使其增加。其他品系显示出肉瘤-180对抗体产生能力的抑制程度以及PS-K使其恢复的程度处于中等水平。在CR品系中，与对照组相比，携带肉瘤-180的小鼠中作为攻击肿瘤的艾氏瘤生长增强。然而，用PS-K处理该品系后，不仅肉瘤-180的生长，而且艾氏瘤的生长也被完全抑制。另一方面，在AKR品系中，携带肉瘤-180的小鼠中艾氏瘤的生长既未增强，也未被PS-K抑制。
