线粒体功能失调抑制人结肠癌细胞中Tim-3-半乳糖凝集素-9分泌途径，因此可能影响肿瘤免疫逃逸。
Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape.
作者信息
Sakhnevych Svetlana S, Yasinska Inna M, Fasler-Kan Elizaveta, Sumbayev Vadim V
机构信息
Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United Kingdom.
Department of Pediatric Surgery and Department of Biomedical Research, Children's Hospital, Inselspital, University of Bern, Bern, Switzerland.
出版信息
Front Pharmacol. 2019 Apr 5;10:342. doi: 10.3389/fphar.2019.00342. eCollection 2019.
The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of this protein (the effect described for various cellular proteins) into mitochondria.
已知Tim-3-半乳糖凝集素-9分泌途径可保护多种类型的癌细胞免受宿主免疫监视。我们发现，药理学诱导的线粒体功能障碍会导致人结肠癌细胞中半乳糖凝集素-9的表达/胞吐作用降低，并使该蛋白（各种细胞蛋白均有此效应）重新分布到线粒体中。
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