Trifluoromethylation and Monofluoroalkenylation of Alkenes through Radical-Radical Cross-Coupling.
作者信息
Wang Qiang, Qu Yi, Tian Hao, Liu Yuxiu, Song Hongjian, Wang Qingmin
机构信息
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Collaborative Innovation Center of Chemical Science, and Engineering (Tianjin), Nankai University, Tianjin, 300071, China.
出版信息
Chemistry. 2019 Jul 2;25(37):8686-8690. doi: 10.1002/chem.201901349. Epub 2019 Jun 5.
The first visible-light-induced trifluoromethylation and monofluoroalkenylation of simple alkenes via a challenging radical-radical cross-coupling step was achieved. This method provided a mild, step-economical and redox-neutral route to privileged two different fluorinated difunctionalized allyl compounds. The utility of this method is illustrated by late-stage modification of medically important molecules.
Zotero 插件