可见光光氧化还原催化烯烃的三氟甲基化反应。
Trifluoromethylation of alkenes by visible light photoredox catalysis.
机构信息
Department of Chemistry and Applied Chemistry, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, ansan, Kyeonggi-do 426-791, Republic of Korea.
出版信息
J Org Chem. 2012 Dec 21;77(24):11383-7. doi: 10.1021/jo3022346. Epub 2012 Nov 30.
PMID:23167602
Abstract
A method for trifluoromethylation of alkenes has been developed employing visible light photoredox catalysis with CF(3)I, Ru(Phen)(3)Cl(2), and DBU. This process works especially well for terminal alkenes to give alkenyl-CF(3) products with only E-stereochemistry. The mild reaction conditions enable the trifluoromethylation of a range of alkenes that bear various functional groups.
摘要
发展了一种可见光光氧化还原催化的三氟甲基化方法，使用 CF(3)I、Ru(Phen)(3)Cl(2) 和 DBU。该方法特别适用于末端烯烃，只能得到 E-立体化学的烯基-CF(3)产物。温和的反应条件使得各种带有不同官能团的烯烃都能够发生三氟甲基化反应。
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