Yamada Sachie, Hasegawa Midori, Nii Norio, Kato Masao, Ohashi Atsushi, Suzuki Ryota, Komatsu Masakazu, Abe Kosei, Hata Yosuke, Takahashi Kazuo, Hayashi Hiroki, Koide Shigehisa, Tsuboi Naotake, Inaguma Daijo, Yuzawa Yukio
Blood Purification Center, Fujita Health University Hospital, Toyoake, Japan.
Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Japan.
Ther Apher Dial. 2019 Jun;23(3):237-241. doi: 10.1111/1744-9987.12821.
Cell-free and concentrated ascites reinfusion therapy (CART) by internal filtration pressure method (internal method) and external filtration pressure method (external method) using the same cancerous ascites was performed. The rate of rise in circuit pressure and recovered components were compared between the two methods. The factors related to circuit pressure rise were also researched. In both methods, circuit pressure rose in 50% of cases. The recovery rates of IgG, IgA, IgM, and haptoglobin were significantly higher for the internal method than for the external method, whereas the recovery rate of α -antitrypsin was significantly lower in the internal method than in the external method. The levels of IL-6, haptoglobin, α -antitrypsin, and fibrinogen/fibrindegradation products (FDP) in the original ascites were significantly higher in the group wherein circuit pressure rose than in that without circuit pressure rise. These proteins might be related to the rise in circuit pressure.
采用相同的癌性腹水，通过内滤压法（内部法）和外滤压法（外部法）进行无细胞浓缩腹水回输治疗（CART）。比较了两种方法之间回路压力的上升速率和回收成分。还研究了与回路压力上升相关的因素。在两种方法中，50%的病例回路压力升高。内部法中IgG、IgA、IgM和触珠蛋白的回收率显著高于外部法，而内部法中α-抗胰蛋白酶的回收率显著低于外部法。回路压力升高组原腹水中IL-6、触珠蛋白、α-抗胰蛋白酶和纤维蛋白原/纤维蛋白降解产物（FDP）的水平显著高于回路压力未升高组。这些蛋白质可能与回路压力升高有关。
